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Models

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Mice

Tgm2-KO

Strain Name：C57BL/6Smoc-Tgm2em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-191051

Exon 3-4 of Tgm2 gene was deleted to generate Tgm2 knockout mice.

Mice

Tgm2-Flox

Strain Name：C57BL/6Smoc-Tgm2em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200229

These mice carry loxP sites flanking exon 5-8 of Tgm2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tgm2 gene.

Mice

Rxrb-Flox

Strain Name：C57BL/6Smoc-Rxrbem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Rxrb gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Rxrb gene.

Mice

Sema7a-Flox

Strain Name：C57BL/6Smoc-Sema7aem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-251710

These mice carry loxP sites flanking exon 2 of Sema7a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Sema7a gene.

Mice

MHCII/B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1B2m em1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-014

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Mice

hPD-1

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00015
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene .

Mice

hPD-L1

Strain Name：C57BL/6Smoc-Cd274tm1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00062
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene . While hPD-L1(2)(Stock No.NM-HU-190039) mice function similarly to hPD-L1 mice,for more detailed information please contact our technical advisor.

Mice

hACE2

Strain Name：C57BL/6Smoc-Ace2tm3(hACE2-flag-Wpre-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200218
Validation Data：Presence  |  Publications：1piece

A human ACE2-flag-Wpre-pA expression cassette was knocked into the Ace2 gene start codon site via CRISPR/Cas9 mediated recombination.

Mice

hCD81

Strain Name：C57BL/6Smoc-Cd81tm1(CD81)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190041

The endogenous mouse Cd81 gene was replaced by human CD81 gene.

Mice

hCD81/hOCLN

Strain Name：C57BL/6Smoc-Cd81tm1(hCD81)Oclntm1(hOCLN)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000107

These mice are obtained through breeding of two single gene humanized mice.

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