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Does a mouse expressing the Cre gene only have a poor phenotype?

Cre activity translocation translocation meaning

How do I breed conventional knockout mice or genetically mutated mice? How do I choose control mice for experiments?

genetically mutated neo gene phenotype definition

Genotyping method for CRISPR/Cas9 point mutation mouse

Genotyping method for CRISPR/Cas9 Knockout mouse

Overview of gene editing technology

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Mouse

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Mice have long been the prime choice for model organisms. In more than 100 years, mice have been widely used by researchers in the fields of physiology, pathology, pharmacology, toxicology, and behavioral science. With the establishment of gene targeting technology, many researchers have made their way to the Nobel Prize.

Popular Model Organisms

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Model organisms are instrumental to the study of gene functions. Gene editing technology has always played a crucial role in the research on gene functions, diseases and drug discovery, through its application in genetic engineering of model organisms, mimicking of human diseases, as well as observation of physiological or pathological changes. In particular, the CRISPR/Cas9 technology has achieved remarkable breakthroughs in recent years, significantly improving the efficiency of genetic engineering in model organisms, and facilitating more extensive and in-depth applications of animal models in various research fields.

Gene Knockout

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Expedite your research with highly customizable, gene knockout mouse models that provide thorough insight into key genetic mechanisms.

Database

mouse genome database

Here you can find links to databases for mouse genomes and other resources.

P53 CKO Mouse Model

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Our own-developed mouse model of p53 conditional knockout (p53-CKO) can be mated with mice carrying tissue-specific Cre expression to obtain mice with homozygous deletion of p53 in specific tissues or cells. These mice can be used for tumorigenesis and tumor mechanistic studies.