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Models

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Mice

hIL6

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18017

This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting.

Mice

Ebf1-Flox

Strain Name：B6;129S-Ebf1tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00065

These mice carry loxP sites flanking exon 3 of the early B cell factor 1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Txnip-KO(2)

Strain Name：C57BL/6Smoc-Txnipem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190894

Using CRISPR/Cas9 technology,exon 2 of Txnip gene was deleted to generate Txnip knockout mice.

Mice

R26-CAG-LSL-mCherry-EGFP-LC3

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-mCherry-EGFP-Map1lc3a-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00124

The CAG promoter-loxp-stop-loxp-mCherry-EGFP-Map1lc3a-WPRE-polyA expression cassette was inserted into the Rosa26 gene locus by homologous recombination. Map1lc3a, also known as LC3, is a widely expressed autophagic vesicle-specific marker. There was no abnormality in heterozygous mice. The presence of the loxp-stop-loxp expression cassette prevented the transcription of the downstream target gene LC3. After mating with Cre mice, LC3 gene is driven by the CAG promoter to express mCherry and EGFP in a pH-dependent manner in phagocytic cells after ischemic injury in the progeny double positive mice. The two co-expressed fluorescent signals vary depending on the acidic environment of the autophagic vesicles within the cell. mCherry is stable in an acidic environment (pKa 4.5), and quenching occurs in the acidic environment (pKa 5.9) of EGFP in lysosomes. In the autophagy vesicles with higher pH, the fluorescence of GFP and mCherry superimposed on yellow fluorescence; while in the lower pH lysosome, EGFP was quenched and only red fluorescence signal was detected. It can be used to label and track LC3 and study the origin, progression and disappearance of autophagy in various tissues after ischemic injury.

Mice

Havcr2-KO

Strain Name：C57BL/6Smoc-Havcr2em3Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18049

This Havcr2 knockout mouse model was generated by knocking out the exon 2-4 region of the Havcr2 gene .

Mice

Zfp42-Flox

Strain Name：B6;129S-Zfp42tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00057

These mice carry loxP sites on either side of exon 5. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Rps5-Flox

Strain Name：B6;129S-Rps5tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00143

These Rps5 flox mice possess loxP sites flanking exons 3-6. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Trp53-Flox

Strain Name：C57BL/6Smoc-Trp53tm2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18005

These Trp53 flox mice possess loxP sites flanking exons 5-7 via ESC targeting. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Il13/Il4-Flox

Strain Name：C57BL/6Smoc-Il13tm1(flox)Il4tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200169

These mice carry loxP sites flanking region between exon 3 of Il13--201 and exon 4 of Il4-201 . When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Il13 and IL4 gene.

Mice

SCID

Strain Name：SCID/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-015

SCID mice, also known as Severe Combined Immune Deficient mice, were first discovered in 1983 by Bosma M.J. from the C.B-17/Icr inbred strain of mice. This condition is caused by a mutation in a single recessive gene located on chromosome 16, also referred to as the SCID gene. SCID mice are a congenic strain of C.B-17/lcrJ, with white fur. This strain exhibits severe combined immune deficiency, characterized by the absence of functional B cells and T lymphocytes. Most homozygotes lack detectable levels of IgM, IgG1, IgG2a, IgG2b, IgG3, or IgA. Additionally, the thymus, lymph nodes, and splenic follicles of these mice are virtually devoid of lymphocytes. However, SCID mice possess normal natural killer (NK) cells, macrophages, and granulocytes. SCID mice are commonly used for the transplantation of allogeneic or xenogeneic tissues and are ideal models for cell transplantation experiments.

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