Welcome to Advanced Search

Models

About 41,400 results
Mice

Il17a-2A-CreERT2

Strain Name:C57BL/6Smoc-Il17aem1(2A-CreERT2)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-00059

A 2A-Cre cassette was inserted before stop codon of mouse Il17a gene which is known as a T cell marker.

Mice

Foxp3-IRES-tdTomato-2A-Cre

Strain Name:C57BL/6Smoc-Foxp3em3(IRES-tdTomato-2A-iCre)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-190119

A IRES-tdTomato-2A-Cre expression cassette was knocked into the Foxp3 gene stop codon site. This strain is useful in studying regulatory T cell in autoimmunity, especially in type 1 diabetes.

Mice

Foxp3-IRES-Luc-2A-tdTomato

Strain Name:C57BL/6Smoc-Foxp3em1(IRES-Luci-2A-tdTomato)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KI-200065

A IRES-luci-2A-tdTomato expression cassette was knocked into the Foxp3 gene stop codon site.

Mice

hIL6

Strain Name:C57BL/6Smoc-Il6tm1(hIL6)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-18017

This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting.

Mice

Txnip-KO(2)

Strain Name:C57BL/6Smoc-Txnipem1Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KO-190894

Using CRISPR/Cas9 technology,exon 2 of Txnip gene was deleted to generate Txnip knockout mice.

Mice

Ebf1-Flox

Strain Name:B6;129S-Ebf1tm1(flox)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-CKO-00065

These mice carry loxP sites flanking exon 3 of the early B cell factor 1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

R26-CAG-LSL-mCherry-EGFP-LC3

Strain Name:C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-mCherry-EGFP-Map1lc3a-pA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-00124

The CAG promoter-loxp-stop-loxp-mCherry-EGFP-Map1lc3a-WPRE-polyA expression cassette was inserted into the Rosa26 gene locus by homologous recombination. Map1lc3a, also known as LC3, is a widely expressed autophagic vesicle-specific marker. There was no abnormality in heterozygous mice. The presence of the loxp-stop-loxp expression cassette prevented the transcription of the downstream target gene LC3. After mating with Cre mice, LC3 gene is driven by the CAG promoter to express mCherry and EGFP in a pH-dependent manner in phagocytic cells after ischemic injury in the progeny double positive mice. The two co-expressed fluorescent signals vary depending on the acidic environment of the autophagic vesicles within the cell. mCherry is stable in an acidic environment (pKa 4.5), and quenching occurs in the acidic environment (pKa 5.9) of EGFP in lysosomes. In the autophagy vesicles with higher pH, the fluorescence of GFP and mCherry superimposed on yellow fluorescence; while in the lower pH lysosome, EGFP was quenched and only red fluorescence signal was detected. It can be used to label and track LC3 and study the origin, progression and disappearance of autophagy in various tissues after ischemic injury.

Mice

Havcr2-KO

Strain Name:C57BL/6Smoc-Havcr2em2Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KO-18049

This Havcr2 knockout mouse model was generated by knocking out the exon 2-4 region of the Havcr2 gene .

Mice

Mt1-Flox/Mt2-Flox

Strain Name:C57BL/6Smoc-Mt1 em1(flox)Mt2 em1(flox)Smoc
Strain State:Developing | Cat. NO.:NM-CKO-252576

The MT1-FLOX model was constructed based on Mt2-Flox (NM-CKO-226357) by inserting loxP sites on both sides of exon 2-3 of the Mt1 gene respectively. This flox mouse can be mated with tissue-specific Cre tool mice to obtain mouse models with the Mt1 gene knocked out in specific cell types or tissues.

Mice

Zfp42-Flox

Strain Name:B6;129S-Zfp42tm1(flox)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-CKO-00057

These mice carry loxP sites on either side of exon 5. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Email Back to top