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Mice

Gli1-CreERT2

Strain Name：C57BL/6Smoc-Gli1em1(CreERT2-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200073

A CreERT2-Wpre-polyA expression cassette was knocked into the Gli1 gene start codon site. Gli1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. When these Gli1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.

Mice

Esco2-Flox

Strain Name：C57BL/6Smoc-Esco2em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200093

These mice carry loxP sites flanking exon 2-3 of Esco2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Esco2 gene.

Mice

Nkx3-1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Nkx3-1em1(IRES-CreERT2)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200071

A IRES-CreERT2 expression cassette was knocked into the Nkx3-1 gene stop codon site.

Mice

Ctnnb1-Flox

Strain Name：C57BL/6Smoc-Ctnnb1em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200154

These mice carry loxP sites flanking exon 2-6 of Ctnnb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ctnnb1 gene.

Mice

Stra8-2A-tdTomato-2A-Cre

Strain Name：C57BL/6Smoc-Stra8em(T2A-tdTomato-P2A-Cre)1Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-225030

T2A-tdTomato－P2A－Cre expression cassette was knocked into the Stra8 gene .

Mice

Pdgfrb-Flox

Strain Name：C57BL/6Smoc-Pdgfrbtm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200204

These mice carry loxP sites flanking exon 3-7 of Pdgfrb gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pdgfrb gene.

Mice

Ncr1-IRES-mtagBFP2-Luc

Strain Name：C57BL/6Smoc-Ncr1em5(IRES-mtagBFP-luciferase)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200030

A IRES-mtagBFP-luciferase expression cassette was knocked into the Ncr1 gene stop codon site.

Mice

Pdgfra-Flox

Strain Name：C57BL/6Smoc-Pdgfratm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200203

These mice carry loxP sites flanking exon 1-4 of Pdgfra gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pdgfra gene.

Mice

Ighm/Ighd-KO

Strain Name：C57BL/6Smoc-Ighmem1Ighdem1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200610

Exon 1-6 of Ighm and exon 1-5 of Ighd gene was deleted to generate Ighm and Ighd knockout mice. Homozygous mutant mice lack mature B cells. It may be useful as a model for B cell immunodeficiency found in humans.

Mice

Atf6-Flox

Strain Name：C57BL/6Smoc-Atf6em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200080

These mice carry loxP sites flanking exon 8-9 of Atf6 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Atf6 gene.

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