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Mice

Gsk3b-Flox

Strain Name：C57BL/6Smoc-Gsk3bem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200098

These mice carry loxP sites flanking exon 2 of Gsk3b gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gsk3b gene.

Mice

Stag2-Flox

Strain Name：C57BL/6Smoc-Stag2tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200138

These mice carry loxP sites flanking exon 7 of Stag2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Stag2 gene.

Mice

Rictor-Flox

Strain Name：C57BL/6Smoc-Rictorem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200214

These mice carry loxP sites flanking exon 11 of Rictor gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Rictor gene.

Mice

Nbn-Flox

Strain Name：C57BL/6Smoc-Nbnem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-241068

These strains carry loxP sites flanking exon 6 of Nbn gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nbn gene.

Mice

Cd19-IRES-EGFP-Luc

Strain Name：C57BL/6Smoc-Cd19em1(IRES-EGFP-Luci)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200058

A IRES-EGFP-Luci expression cassette was knocked into the Cd19 gene stop codon site.

Mice

Tagln-Cre

Strain Name：C57BL/6Smoc-Taglnem1(Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200144

A Cre-WPRE-polyA expression cassette was knocked into the Tagln gene start codon site. This gene encodes a smooth muscle cell-specific cytoskeletal protein. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in vascular smooth muscle cells. In mouse models of atherosclerosis, the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis.

Mice

Gli1-CreERT2

Strain Name：C57BL/6Smoc-Gli1em1(CreERT2-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200073

A CreERT2-Wpre-polyA expression cassette was knocked into the Gli1 gene start codon site. Gli1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. When these Gli1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.

Mice

Wnt1-Dre

Strain Name：C57BL/6Smoc-Wnt1em1(Dre-Wpre-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200176

A Dre-Wpre-polyA expression cassette was knocked into the Wnt1 gene start codon site. Wnt1 gene is involved in stem cell poliferation in multiple systems, including the hematopoietic system and the embryonic nervous system. This strain may be useful for studying central nervous system development. When crossed with a strain carrying a gene flanked by rox sites, the flanked gene will be removed in cells expressing dre.

Mice

Nkx3-1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Nkx3-1em1(IRES-CreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200071

A IRES-CreERT2 expression cassette was knocked into the Nkx3-1 gene stop codon site.

Mice

Ctnnb1-Flox

Strain Name：C57BL/6Smoc-Ctnnb1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200154

These mice carry loxP sites flanking exon 2-6 of Ctnnb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ctnnb1 gene.

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