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Mice

Plp1-Flox

Strain Name：C57BL/6Smoc-Plp1em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200072

These mice carry loxP sites flanking exon 3 of Plp1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Plp1 gene.

Mice

Axin2-CreERT2

Strain Name：C57BL/6Smoc-Axin2em1(CreERT2-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200109
Validation Data：Presence

A CreERT2-pA expression cassette was knocked into the Axin2 gene start codon site. As Axin2 is an intracellular protein, it is essential for identifying a surface marker for stem cell purification. When these Axin2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Axin2 expressing cells.

Mice

Braf-Flox

Strain Name：C57BL/6Smoc-Brafem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200073

These mice carry loxP sites flanking exon 5 of Braf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Braf gene.

Mice

Glp1r-IRES-Cre

Strain Name：C57BL/6Smoc-Glp1rem1(IRES-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200134
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Glp1r gene stop codon site.

Mice

Foxn1-IRES-Cre

Strain Name：C57BL/6Smoc-Foxn1em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200106
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.

Mice

Sox9-IRES-CreERT2

Strain Name：C57BL/6Smoc-Sox9em(IRES-CreERT2-SV40pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-204996
Validation Data：Presence  |  Publications：1piece

IRES-CreERT2-SV40pA expression cassette was knocked into the Sox9 gene .

Mice

Clec4f-IRES-DTRGFP

Strain Name：C57BL/6Smoc-Clec4fem1(IRES-DTRGFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200070

A IRES-DTRGFP expression cassette was knocked into the Clec4f gene stop codon site.

Mice

Il17a-Cre

Strain Name：C57BL/6Smoc-Il17aem1(iCre-polyA(SV40))Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200137
Validation Data：Presence

A iCre-polyA expression cassette was knocked into the Il17a gene start codon site. This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying autoimmune inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis.

Mice

Postn-2A-CreERT2

Strain Name：C57BL/6Smoc-Postnem(2A-CreERT2)1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-225034

2A-CreERT2 expression cassette was knocked into the Postn gene .

Mice

Notch1-CreERT2

Strain Name：C57BL/6Smoc-Notch1em1(CreERT2-2xpA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200122
Validation Data：Presence

A CreERT2-2xpA expression cassette was knocked into the Notch1 gene start codon site. Notch1 performs vital cell functions, such as proliferation, differentiation, apoptosis, and stem cell maintenance. When Notch1-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in NOTCH1 positive cells.

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