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Models

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Mice

MHCII/B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1B2m em1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-014

All sequences from the upstream of  mouse H2-Ab1 gene exon 2  to the upstream of the H2-Ea-ps gene  exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

Txlna-KO

Strain Name：C57BL/6Smoc-Txlnaem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00123

Exon1 of Txlna gene was deleted to generate Txlna knockout mice.

Mice

Smurf2-KO

Strain Name：C57BL/6Smoc-Smurf2em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 3 of Smurf2 gene was deleted to generate Smurf2 knockout mice.

Mice

Bcl9l-KO

Strain Name：C57BL/6Smoc-Bcl9lem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200055

Exon 6 of Bcl9l gene was deleted to generate Bcl9l knockout mice.

Mice

Faf1-KO

Strain Name：C57BL/6Smoc-Faf1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-191163

Exon 3 of Faf1 gene was deleted to generate Faf1 knockout mice.

Mice

Chgb-KO

Strain Name：C57BL/6Smoc-Chgbem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190935

Exon 2 of Chgb gene was deleted to generate Chgb knockout mice.

Mice

Fhit-KO

Strain Name：C57BL/6Smoc-Fhitem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190624

Exon 4 of Fhit gene was deleted to generate Fhit knockout mice.

Mice

Bcl7a-KO

Strain Name：C57BL/6Smoc-Bcl7aem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200051

Exon 2 of Bcl7a gene was deleted to generate Bcl7a knockout mice.

Mice

Prkcb-KO

Strain Name：C57BL/6Smoc-Prkcbem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190859

Exon 2 of Prkcb gene was deleted to generate Prkcb knockout mice.

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