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Models

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Mice

MHCII/B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1B2m em1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-014

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039
Validation Data：Presence  |  Publications：2piece

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

Txlna-KO

Strain Name：C57BL/6Smoc-Txlnaem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00123

Exon1 of Txlna gene was deleted to generate Txlna knockout mice.

Mice

Cldn16-KO

Strain Name：C57BL/6Smoc-Cldn16em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200632

Exon 2 of Cldn16 gene was deleted to generate Cldn16 knockout mice.

Mice

Smarcad1-KO

Strain Name：C57BL/6Smoc-Smarcad1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200643

Exon 3 of Smarcad1 gene was deleted to generate Smarcad1 knockout mice.

Mice

Il34-KO

Strain Name：C57BL/6Smoc-Il34em2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190501

Exon 3 of Il34 gene was deleted to generate Il34 knockout mice.

Mice

Ccr4-KO

Strain Name：C57BL/6Smoc-Ccr4em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-191195

Exon 2 of Ccr4 gene was deleted to generate Ccr4 knockout mice.

Mice

Clu-KO

Strain Name：C57BL/6Smoc-Cluem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190782

Exon 3 of Clu gene was deleted to generate Clu knockout mice.

Mice

Il12a-KO

Strain Name：C57BL/6Smoc-Il12aem2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190454

Exon 2 of Il12a gene was deleted to generate Il12a knockout mice.

Mice

Il15-KO

Strain Name：C57BL/6Smoc-Il15em2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190459

Exon 5 of Il15 gene was deleted to generate Il15 knockout mice.

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