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Models

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Mice

Nek5-Flox

Strain Name：C57BL/6Smoc-Nek5em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-2116908

These mice carry loxP sites flanking target exon 3 of Nek5 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nek5 gene.

Mice

Nedd8-Flox

Strain Name：C57BL/6Smoc-Nedd8em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-233829

These strains carry loxP sites flanking exon 2-3 of Nedd8 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nedd8 gene.

Mice

Pdcd10-Flox

Strain Name：B6;129S-Pdcd10tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00079

An frt-neo-frt cassette was inserted after exon 4 of Pdcd10 gene and loxP sites was inserted before exon 4 and after the neo cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional

Mice

Igf2bp3-Flox

Strain Name：C57BL/6Smoc-Igf2bp3em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-2110528

These mice carry loxP sites flanking target exon 4-5 of Igf2bp3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Igf2bp3 gene.

Mice

Men1-Flox

Strain Name：C57BL/6Smoc-Men1em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-2101472

These mice carry loxP sites flanking target exon 3-8 of Men1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Men1 gene.

Mice

Nell2-Flox

Strain Name：C57BL/6Smoc-Nell2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2103411

These mice carry loxP sites flanking target exon 5-6 of Nell2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nell2 gene.

Mice

Foxd1-Cre-pGK-Neo

Strain Name：C57BL/6Smoc-Foxd1em1(Kozak-Cre-pA-pGK-Neo)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-241417

The Kozak-Cre-pA-pGK-Neo expression cassette was knocked into the Foxd1 gene start codon site.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Pcp2-Cre-PGK-Neo

Strain Name：C57BL/6Smoc-Pcp2em1(Cre-FRT-PGK-Neo-pA-FRT)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-241053

The Cre-FRT-PGK-Neo-pA-FRT expression cassette was knocked into the Pcp2 gene locus.

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