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Mice

Gli1-CreERT2

Strain Name：C57BL/6Smoc-Gli1em1(CreERT2-Wpre-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200073

A CreERT2-Wpre-polyA expression cassette was knocked into the Gli1 gene start codon site. Gli1 encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. When these Gli1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Gli1 expressing cells; making them useful for studying axis patterning, proliferation, and cell fate specification of Hedgehog responding cells at different stages of embryogenesis.

Mice

Prox1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Prox1em1(IRES-CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200119

A IRES-CreERT2-pA expression cassette was knocked into the Prox1 gene stop codon site. Prox1 encodes a transcription factor (prospero-related homeobox 1) that is necessary for the formation and maintenance of lymphatic vessels. When Prox1-IRES-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in PROX1positive cells.

Mice

Upk3b-KO

Strain Name：B6;129S-Upk3btm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00023

An Frt-Neo-Frt cassette replaced exons 1-2 of Upk13 gene.

Mice

Cdkn1a-Flox

Strain Name：C57BL/6Smoc-Cdkn1aem2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200033

These mice carry loxP sites flanking exon 2-3 of Cdkn1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cdkn1a gene.

Mice

Pvr-Flox

Strain Name：C57BL/6Smoc-Pvrtm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-231272

These strains carry loxP sites flanking exon 2-4 of Pvr gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pvr gene.

Mice

Nectin4-Flox

Strain Name：C57BL/6Smoc-Nectin4em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-231327

These strains carry loxP sites flanking exon 3-4 of Nectin4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nectin4 gene.

Mice

Nek1-Flox(2)

Strain Name：C57BL/6Smoc-Nek1em2(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-215041

These mice carry loxP sites flanking exon 4-8 of Nek1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nek1 gene.

Mice

Igf2bp2-Flox

Strain Name：C57BL/6Smoc-Igf2bp2em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200101

These mice carry loxP sites flanking exon 3-4 of Igf2bp2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Igf2bp2 gene.

Mice

Tespa1-KO

Strain Name：B6;129S-Tespa1tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00036

An Frt-Neo-Frt cassette replaced exons 2-3 of 5830405N20Rik gene.

Mice

Oosp1-KO

Strain Name：B6;129S-Oosp1tm1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-00030

An Frt-Neo-Frt cassette replaced exons 2-3 of Oosp1 gene.

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