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Models

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Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

Nmu-2A-Cre

Strain Name：C57BL/6Smoc-Nmuem1(2A-Cre-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200298

2A-Cre-WPRE-polyA expression cassette was knocked into the Nmu gene stop codon site. Nmu gene encodes a member of the neuromedin family of neuropeptides. The encoded protein plays a role in energy homeostasis and body temperature regulation. And the protein is homologous with human NMU, which is linked toobesity.

Mice

Foxn1-IRES-Cre

Strain Name：C57BL/6Smoc-Foxn1em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200106

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.

Mice

Il13-IRES-Cre

Strain Name：C57BL/6Smoc-Il13em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200166

A IRES-iCre expression cassette was knocked into the Il13 gene stop codon site. This gene encodes a multifunctional cytokine. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This cytokine participates in the regulation of immune response, inflammatory response and hematopoietic process.

Mice

Opn4-Cre

Strain Name：C57BL/6Smoc-Opn4em1(Cre-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200304

Cre-WPRE-polyA expression cassette was knocked into the Opn4 gene start codon site. The melanopsin gene (Opn4) encodes a functional photopigment. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying circadian rhythm regulation.

Mice

Hamp2-KO

Strain Name：C57BL/6Smoc-Hamp2em1Smoc
Strain State：Developing | Cat. NO.：NM-KO-200699

Exon 1 of Hamp2 gene was deleted to generate Hamp2 knockout mice.

Mice

Ace2-KO

Strain Name：C57BL/6Smoc-Ace2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190906

exon 3-7 of Ace2 gene was deleted to generate Ace2 knockout mice.

Mice

Phf3-KO

Strain Name：C57BL/6Smoc-Phf3em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190851

Exon 3 of Phf3 gene was deleted to generate Phf3 knockout mice.

Mice

Cfhr2-KO

Strain Name：C57BL/6Smoc-Cfhr2em1Smoc
Strain State：Developing | Cat. NO.：NM-KO-200683

Exon 3-6 of Cfhr2 gene was deleted to generate Cfhr2 knockout mice.

Mice

Pard6g-KO

Strain Name：C57BL/6Smoc-Pard6Gem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-191004

Exon 1 of Pard6g gene was deleted to generate Pard6g knockout mice.

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