Welcome to Advanced Search

Models

About 40,732 results
Mice

KPC

Strain Name：C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Mice

Chd7-Flox

Strain Name：C57BL/6Smoc-Chd7em1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-250746

These strains carry loxP sites flanking exon 3 of Chd7 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Chd7 gene.

Mice

Snap25-Flox

Strain Name：B6;129S-Snap25tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00091

These mice carry loxP sites flanking exon 4 of Snap25 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Atp2b2-Flox

Strain Name：C57BL/6Smoc-Atp2b2em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Atp2b2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Atp2b2 gene.

Mice

Flna-Flox

Strain Name：C57BL/6Smoc-Flnaem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-232177

These strains carry loxP sites flanking exon 3-7 of Flna gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Flna gene.

Mice

Gars-Flox

Strain Name：C57BL/6Smoc-Garsem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Gars gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Gars gene.

Mice

Nefh-Flox

Strain Name：C57BL/6Smoc-Nefhem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-205123

These mice carry loxP sites flanking exon3 of Nefh gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nefh gene.

Mice

Nexn-Flox

Strain Name：C57BL/6Smoc-Nexnem1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Nexn gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Nexn gene.

Mice

Ikbkg-Flox

Strain Name：C57BL/6Smoc-Ikbkgem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-2100819

These mice carry loxP sites flanking exon 4 of Ikbkg gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ikbkg gene.

Mice

Zfp618-Flox

Strain Name：C57BL/6Smoc-Zfp618em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Zfp618 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Zfp618 gene.

Email Back to top