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Mice

Dipk2b-Flox

Strain Name：B6;129-Dipk2btm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00003

These mice possess loxP sites on either side of exon 2 and followed by an frt-neo-frt cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Vstm2a-Flox

Strain Name：B6;129S-Vstm2atm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00010

These mice possess loxP sites on either side of exon 2 and followed by an frt-neo-frt cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Garnl3-Flox

Strain Name：B6;129S-Garnl3tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00007

These mice possess loxP sites on either side of exon 5 and followed by an frt-neo-frt cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Lyar-Flox

Strain Name：B6;129S-Lyartm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00032

These mice possess loxP sites on either side of exon 3 and followed by an frt-neo-frt cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Asap3-Flox

Strain Name：B6;129S-Asap3tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00038

These mice possess loxP sites on either side of exon 5 and then followed by an frt-neo-frt cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Vps53-Flox

Strain Name：B6;129S-Vps53tm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00036

These mice possess loxP sites on either side of exon 6 and then followed by an frt-neo-frt cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Fau-Flox

Strain Name：B6;129S-Fautm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00048

These mice possess loxP sites flanking exons 2-5(followed by an frt-neo-frt cassette). When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Abi3bp-Flox

Strain Name：B6;129S-Abi3bptm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00009

An frt-neo-frt cassette was inserted before exon 4. And these mice possess loxP sites on either side of exon 4. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

BC028528-Flox

Strain Name：B6;129S-BC028528tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-00012

An frt-neo-frt cassette was inserted before exon 3. And these mice possess loxP sites on either side of exon 3. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

KPC

Strain Name：C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

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