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Solutions from PCC to IND Drug Development

Some Basics about Cre-lox and Inducible Cre in Mouse Modeling

Popular Model Organisms

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Model organisms are instrumental to the study of gene functions. Gene editing technology has always played a crucial role in the research on gene functions, diseases and drug discovery, through its application in genetic engineering of model organisms, mimicking of human diseases, as well as observation of physiological or pathological changes. In particular, the CRISPR/Cas9 technology has achieved remarkable breakthroughs in recent years, significantly improving the efficiency of genetic engineering in model organisms, and facilitating more extensive and in-depth applications of animal models in various research fields.

Pharmacodynamics Analysis & Evaluation

Based on the U-GEMM repository, the pharmacodynamics evaluation service from Shanghai Model Organisms can conduct main pharmacodynamics study on the drugs for anti-inflammatory-immunity, antineoplastic, cardiovascular system, respiratory system and metabolic diseases,etc, satisfy the study requirements of different layers of in vivo experiments, mechanism investigation and molecular biological study, and confirm the effectiveness and safety of new drug(s).

薬効の分析と評価

上海南方モデル動物バイオテクノロジー株式会社（Shanghai Model Organisms Center, Inc）の薬力学的評価サービスは、二十年の業界経験を積み重ねて、自社開発のU-GEMM®モデルマウスリソースライブラリーを利用して、抗炎免疫、抗腫瘍、心臓血管系、呼吸器系、代謝性疾患など薬物のスクリーニングをする為に、研究者様の求めに応じて 、in vivo 実験、メカニズムの検討、分子生物学研究などの異なるレベルの研究ニーズを満足し、新薬の有効性と安全性を明らかにし、国内外の製薬会社、生物医薬研究機関、新薬開発センター、大学の新薬開発機関などに、専門的な薬力学的評価サービスを提供しております。

Services

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Shanghai Model Organisms offers a full range of model organism services, including model customization services, research-ready models, breeding, phenotyping and drug screening. Mouse, rat, zebrafish and C. elegans models are available to meet different research needs.

약물 효과 분석 및 평가

Shanghai Model Organisms Center, Inc.(사)는 약물 효과 평가 서비스는 U-GEMMs 리소스 라이브러리를 기반으로 하여 항염 면역, 항종양, 심혈관계, 호흡계, 대사성 질병 등 약물의 주요 약력학 연구를 수행할 수 있으며, 체내 실험, 메커니즘 검토 및 분자생물학 연구 등 서로 다른 수준의 연구 수요를 충족시켜 신약의 유효성과 안전성을 확립하고 국내외의 제약업체, 생물의학연구소, 신약개발센터, 고등교육기관의 신약 연구개발 기관 등에 전문적인 약력학 평가 서비스를 제공합니다.

Construction of Overexpression Cell Line

Humanized Mice

NMG and NMG-B2m mice transplanted with human-derived PBMC are suitable for short-term in vivo tests requiring mature T cell function, including studies on HIV infection, immuno-oncology and GvHD.

Analysis of Antibody Specificity