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Models

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Mice

hIL7R

Strain Name：C57BL/6Smoc-Il7rtm1(hIL7R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210027

The endogenous mice Il7r gene was completely or partially replaced by human IL7R gene via ESC targeting.

Mice

hPSGL-1(2)

Strain Name：C57BL/6Smoc-Selplgem2(hSELPLG)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210026

The endogenous mice Selplg gene was completely or partially replaced by human SELPLG gene via CRISPR/Cas9 mediated recombination.

Mice

hLILRB4

Strain Name：C57BL/6Smoc-Lilrb4aem1(hLILRB4 )Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210024

The endogenous mice Lilrb4a gene was completely or partially replaced by human LILRB4 gene via CRISPR/Cas9 mediated recombination.

Mice

hHLA-E

Strain Name：C57BL/6Smoc-Igs2em1(hHLA-E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200221

The endogenous human HLA-E gene (about 11kb) was knocked into the H11 locus via CRISPR/Cas9 mediated recombination.

Mice

R26-CAG-LSL-hMET-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-c-MET-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18052

A SA-2xpolyA-CAG-Loxp-Stop-Loxp-human cMET-IRES-luciferase-2A-tdTomato-wpre-polyA cassette was knocked into the mouse Rosa26 locus . This strain of mice can be mated with mice expressing Cre recombinase so that human C-MET could be expressed after exposure to Cre recombinase.

Mice

R26-LSL-hEZH2-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-EZH2-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18053

A SA-2xpolyA-CAG-Loxp-Stop-Loxp-human EZH2 cDNA-IRES-luciferase-2A-tdTomato-wpre-polyA cassette was knocked into the mouse Rosa26 locus . This strain of mice can be mated with mice expressing Cre recombinase so that human EZH2 could be expressed after exposure to Cre recombinase.

Mice

R26-CAG-LSL-hNRF2-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-NRF2-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18050

A SA-2xpolyA-CAG-LSL-human NRF2-IRES-luciferase-2A-tdTomato-wpre-polyA cassette was knocked into the mouse Rosa26 locus . This strain of mice can be mated with mice expressing Cre recombinase to express human NRF2 and a reporter gene in certain cells or tissues that expressing Cre recombinase.

Mice

Taz-Flox

Strain Name：C57BL/6Smoc-Tazem2(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200001

These mice carry loxP sites flanking exon5-10 of Taz gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Taz gene.

Mice

hPD-L1/hSTING

Strain Name：C57BL/6Smoc-Tmem173tm1(hTMem173)Cd274em1(hCD274)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000105

hPD-L1(NM-HU-00062) was crossed with hSTING(NM-HU-190036) to generate hPD-L1/hSTING.

Mice

hPD-L1/hVISTA

Strain Name：C57BL/6Smoc-Visrem1(hVSIR)Cd274em1(hCD274)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000094

hPD-L1(NM-HU-00062) was crossed with hVISTA(NM-HU-00118) to generate hPD-L1/hVISTA.

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