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NOD SCID

Strain Name：NOD.Cg-Prkdc^scid/NifdcSmoc
Strain State：Repository Live | Cat. NO.：SM-019
Validation Data：Presence

The strain was developed on background of non-obese diabetic (NOD) mouse with spontaneous scid mutation. NOD SCID mouse, insusceptible to diabetes, possesses reduced activity of T cells and B cells, and defect in innate immunity.NOD SCID mouse is compatible with a wider range of engraftment of cell lines in comparison with nude mouse; And it is broadly applied to construction of PDX models. However, due to a short life span(8-9 months) caused by lethal thymic lymphomas, it is unsuitable for long-term in vivo assays.

Ager-KO

Strain Name：C57BL/6Smoc-Ager^em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-200021

Exon 2 of Ager gene was deleted to generate Ager knockout mice.

Aoc3-KO

Strain Name：C57BL/6Smoc-Aoc3^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200031

Exon 1-4 of Aoc3 gene was deleted to generate Aoc3 knockout mice.

Igfbp7-KO

Strain Name：C57BL/6Smoc-Igfbp7^em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200260

Exon 1-2 of Igfbp7 gene was deleted to generate Igfbp7 knockout mice.

Fibroblast-specific activation of Rnd3 protects against cardiac remodeling in diabetic cardiomyopathy via suppression...

Model Organisms：小鼠 Product & Service：Col1a2-2A-Cre Research field：

Cyclin G2 regulates canonical Wnt signalling via interaction with Dapper1 to attenuate tubulointerstitial fibrosis i...

Model Organisms：Mouse Product & Service：Ccng2 Research field：diabetic nephropathy

Endocrinology and Metabolism

Diabetic mouse model type 2 diabetes mouse model

Long-term feeding of high-fat diets can cause obesity and increased fasting blood glucose in mice along with fat accumulation and insulin resistance in the body to mimic human type II diabetes.

Excision and Regeneration of Tissue

liver regeneration subtotal gastrectomy

A mouse tissue regeneration model can be established by an operation of partial tissue excision. Such models can be used to study the changes in morphology, serology and metabolism during tissue regeneration, and hence lay the experimental foundation for studying the mechanisms regulating tissue regeneration.