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Crisp4-Flox

Strain Name：C57BL/6Smoc-Crisp4^{em1(flox)Smoc}
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Crisp4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Crisp4 gene.

Crisp1-KO

Strain Name：C57BL/6Smoc-Crisp1^em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 3-4 of Crisp1 gene was deleted to generate Crisp1 knockout mice.

Crisp4-KO

Strain Name：C57BL/6Smoc-Crisp4^em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 3 of Crisp4 gene was deleted to generate Crisp4 knockout mice.

Crisp2-Flox

Strain Name：C57BL/6Smoc-Crisp2^{em1(flox)Smoc}
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Crisp2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Crisp2 gene.

Crisp1-Flox

Strain Name：C57BL/6Smoc-Crisp1^{em1(flox)Smoc}
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Crisp1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Crisp1 gene.

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher).

Foxn1-KO(SD)

Strain Name：SD-Foxn1^em1Smoc Strain State：Embryo cryopreservation | Cat. NO.：NR-KO-190002

Using CRISPR/Cas9 technology, Exon 2-4 of Foxn1 gene was deleted to generate Foxn1 knockout rat.

F8-KO(SD)

Strain Name：SD-F8^em1Smoc Strain State：Repository Live | Cat. NO.：NR-KO-200003

Using CRISPR/Cas9 technology, exon 16 of F8 gene was deleted to generate F8 knockout rat.

CRISPR/Cas9-mediated somatic and germline gene correction to restore hemostasis in hemophilia B mice

Model Organisms：小鼠 Product & Service：F9 Research field：hemophilia

CRISPR/Cas9‑mediated somatic and germline gene correction to restore hemostasis in hemophilia B mice

Model Organisms：Mouse Product & Service：F9 Research field：Hemophilia