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Mice

Upk3a-2A-GFPCre

Strain Name：C57BL/6Smoc-Upk3aem1(2A-EGFP-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-210003

2A-EGFP-Cre expression cassette was knocked into the Upk3a gene .

Mice

Calb1-2A-GFPCre

Strain Name：C57BL/6Smoc-Calb1em1(2A-EGFP-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200141
Validation Data：Presence

A 2A-EGFP-Cre expression cassette was knocked into the Calb1 gene stop codon site. Calb1 is highly expressed in the brain. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. This strain is useful in studying many neurobehavioral diseases such as spatial learning and circadian rhythm interference. It has been reported that the incidence of many diseases may be different between genders.

Mice

Piezo2-2xMyr-mGreenLantern-3xFLAG-IRES-CrexER

Strain Name：C57BL/6Smoc-Piezo2em1(Kozak-2xMyr-mGreenLantern-3xFLAG-IRES-Cre-rox-ERT2-rox-WPRE-pA)Smoc
Strain State：Developing | Cat. NO.：NM-KI-260333

The Kozak-2xMyr-mGreenLantern-3xFLAG-IRES-Cre-rox-ERT2-rox-WPRE-pA expression cassette was knocked into the Piezo2 gene start codon site.

Mice

KPC

Strain Name：C57BL/6Smoc-Trp53em4(R172H)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210096
Validation Data：Presence

The KPC mouse is an established and clinically relevant model of pancreatic ductal adenocarcinoma (PDAC) which develops many key features observed in human PDAC including pancreatic intraepithelial neoplasia alongside a robust inflammatory reaction including exclusion of effector T cells. Metastases are observed in around 80% of KPC animals located primarily in the liver and lungs. Mutations in both KRAS and TP53 genes are found in around 80% and 70% of all human PDACs respectively. Trp53-R172H、Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. The KPC mouse contains a dominant negative point mutation in the transformation related protein 53 gene (TP53R172H), and a conditional activation point mutation in the KRAS gene (KRASG12D). A lox-stop-lox termination sequence is encoded upstream of KRAS mutated genes to prevent expression in the absence of Cre recombinase. The pancreas-specific Pdx-1 promoter enables expression of Cre recombinase in acini, islet and duct cells of the pancreas. Cre-mediated recombination excises the lox-stop-lox termination sequences and enables expression of KRASG12D in pancreatic tissue.

Mice

KPC(2)

Strain Name：C57BL/6Smoc-Trp53tm7(R270H-flox)Krasem4(LSL-G12D)Tg(Pdx1-cre)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-220014

Trp53-LSL-R270H, Kras-LSL-G12D were crossed with Pdx1-Cre-Tg to generate KPC mice. While KPC mice function similarly to KPC(2) mice, for more detailed information please contact our technical advisor.

Mice

Fap-Flox/Pax7-IRES-CreERT2

Strain Name：C57BL/6Smoc-Faptm1(flox)Pax7em1(IRES-Cre-ERT2)Smoc
Strain State：Developing | Cat. NO.：NM-XA-251979

The Fap-Flox (NM-CKO-231298) was crossed with Pax7-IRES-CreERT2(NM-KI-200099) to generate Fap-Flox/Pax7-IRES-CreERT2 mice.

Mice

KPC(3)

Strain Name：C57BL/6Smoc-Krasem4(LSL-G12D)Trp53tm(LSL-R172H)Tg(Pdx1-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-234804

The Kras-LSL-G12D/Pdx1-Cre-Tg was crossed with Trp53-LSL-R172H to generate KPC(3) mice.

Mice

R26-CAG-hPNPLA3-I148M-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-Frt-2xpolyA-CAG-Frt-LSL-PNPLA3 I148M-IRES-GFP-wpre-polyA)Dppa3tm1(IRES-Cre)Smoc
Strain State：Repository Live | Cat. NO.：NM-XA-242479
Validation Data：Presence

The R26-CAG-LSL-hPNPLA3*I148M-EGFP(NM-KI-200013) was crossed with Dppa3-IRES-Cre(NM-KI-00040) to generate R26-CAG-LSL-hPNPLA3*I148M-EGFP/Dppa3-IRES-Cre mice.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025
Publications：1piece

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain also explicitly states that fluorescence cannot be directly observed.

Mice

Bmal1-Flox

Strain Name：C57BL/6Smoc-Bmal1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200063

These mice carry loxP sites flanking exon 8 of Bmal1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bmal1 gene.

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