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Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain also explicitly states that fluorescence cannot be directly observed.

Mice

Bmal1-Flox

Strain Name：C57BL/6Smoc-Bmal1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200063

These mice carry loxP sites flanking exon 8 of Bmal1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Bmal1 gene.

Mice

Hif1a-Flox

Strain Name：C57BL/6Smoc-Hif1atm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190065

These mice carry loxP sites flanking exon 2 of Hif1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Hif1a gene.

Mice

Chi3l1-Flox

Strain Name：C57BL/6Smoc-Chil1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-241991

These strains carry loxP sites flanking exon 3-5 of Chil1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Chil1 gene.

Mice

Eef2kmt-Flox

Strain Name：C57BL/6Smoc-Eef2kmtem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-234542

These strains carry loxP sites flanking exon 3-6 of Eef2kmt gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Eef2kmt gene.

Mice

Pdcd1-Flox

Strain Name：C57BL/6Smoc-Pdcd1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-210063

These mice carry loxP sites flanking exon 2-4 of Pdcd1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pdcd1 gene.

Mice

Arg1-Flox

Strain Name：C57BL/6Smoc-Arg1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200062

These mice carry loxP sites flanking exon 5-8 of Arg1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Arg1 gene.

Mice

Ern1-Flox

Strain Name：B6;129S-Ern1tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-00077

An frt-neo-frt cassette was inserted after exon 2 and loxP sites was inserted before exon 2 and after the neo cassette. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of t

Mice

Il17a-2A-CreERT2

Strain Name：C57BL/6Smoc-Il17aem1(2A-CreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00059

A 2A-Cre cassette was inserted before stop codon of mouse Il17a gene which is known as a T cell marker.

Mice

Il10-KO

Strain Name：C57BL/6Smoc-Il10tm1.1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190426

This Il10 knockout strain is established by crossing Il10-CKO and Dppa3-Cre mice strains together. The Il10 flox mice possess loxP sites flanking exons 1 .

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