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Models

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Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

Tgfbr2-Flox

Strain Name：C57BL/6Smoc-Tgfbr2tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200026

These mice carry loxP sites flanking exon 3 of Tgfbr2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tgfbr2 gene.While Tgfbr2-Flox(2)(Stock No.NM-CKO-200228)mice carrying the loxP sites flanking exon 4 of Tgfbr2 gene.

Mice

Kras-LSL-G12D

Strain Name：C57BL/6Smoc-Krasem4(LSL-G12D)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190003

exon2 of Kras were replaced by loxp-stop-loxp and exon2 containing G12D. When crossed with a Cre recombinase-expressing strain, this strain is useful in studies of cancer and development.

Mice

Smarcb1-Flox

Strain Name：C57BL/6Smoc-Smarcb1tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190042

These mice carry loxP sites flanking exon2 of Smarcb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Smarcb1 gene.

Mice

Ncstn-Flox

Strain Name：C57BL/6Smoc-Ncstnem1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-241011

These strains carry loxP sites flanking exon 3 of Ncstn gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ncstn gene.

Mice

Foxo3-Flox

Strain Name：C57BL/6Smoc-Foxo3em1(flox)Smoc
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Foxo3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Foxo3 gene.

Mice

Tcf7l2-Flox

Strain Name：C57BL/6Smoc-Tcf7l2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200141

These mice carry loxP sites flanking exon 1-3 of Tcf7l2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tcf7l2 gene.

Mice

Mrc2-KO

Strain Name：C57BL/6Smoc-Mrc2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190216

This Mrc2 knockout mouse model was generated by knocking out the exon3-8 region of the Mrc2.

Mice

Stc1-KO

Strain Name：C57BL/6Smoc-Stc1em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190386

This Stc1 knockout mouse model was generated by knocking out the exon2 region of the Stc1 .

Mice

Tmprss2-KO

Strain Name：C57BL/6Smoc-Tmprss2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200647

Exon 3 of Tmprss2 gene was deleted to generate Tmprss2 knockout mice.

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