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Mice

Fzd10-KO

Strain Name：C57BL/6Smoc-Fzd10em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200211

Exon 1 of Fzd10 gene was deleted to generate Fzd10 knockout mice.

Mice

Lpar2-KO

Strain Name：C57BL/6Smoc-Lpar2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200338

Lpar2-KO mice(Stock No.NM-KO-200338) carry a knockout allele derived from the targeted deletion of exon 2-3. While Lpar2-KO(2) mice(Stock No.NM-KO-210258)carrying the exon 2 deletion.

Mice

Smad5-Flox

Strain Name：C57BL/6Smoc-Smad5tm(flox)1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-18017

These mice carry loxP sites flanking exon2 of the Smad5 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Ctnnb1-Flox

Strain Name：C57BL/6Smoc-Ctnnb1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200154

These mice carry loxP sites flanking exon 2-6 of Ctnnb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ctnnb1 gene.

Mice

Braf-Flox

Strain Name：C57BL/6Smoc-Brafem1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200073

These mice carry loxP sites flanking exon 5 of Braf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Braf gene.

Mice

Cnst-KO

Strain Name：C57BL/6Smoc-Cnstem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200134

Exon 3 of Cnst gene was deleted to generate Cnst knockout mice.

Mice

Stk4-KO

Strain Name：C57BL/6Smoc-Stk4em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-191039

Stk4-KO mice(Stock No.NM-KO-191039）carry a knockout allele derived from the targeted deletion of exon 3-4.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

R26-CAG-LSL-hHER2-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-HER2-luciferase-EGFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190008

A SA-2xpolyA-CAG-LSL-HER2-IRES-Luciferase-2A-EGFP-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the HER2 protein.

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