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Models

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Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：Presence  |  Publications：5piece

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

R26-CAG-LSL-hHER2-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-2xpolyA-CAG-LSL-HER2-luciferase-EGFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190008

A SA-2xpolyA-CAG-LSL-HER2-IRES-Luciferase-2A-EGFP-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the HER2 protein.

Mice

R26-CAG-LSL-hEML4/ALK*F1174L-Luc-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-luciferase-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190010

A SA-2xpolyA-CAG-LSL-EML4-ALK(F1174L)-IRES-Luciferase-2A-tdTomato-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the EML4-ALK(F1174L) protein.

Mice

R26-CAG-LSL-hFGFR2-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(SA-2xpolyA-CAG-LSL-FGFR2-luciferase-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190007

A SA-2xpolyA-CAG-LSL-FGFR2-IRES-luciferase-2A-EGFP-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the FGFR2 protein.

Mice

Inppl1-KO

Strain Name：C57BL/6Smoc-Inppl1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190824

Exon 5 of Inppl1 gene was deleted to generate Inppl1 knockout mice.

Mice

Cdkn2a-KO(p19-KO)

Strain Name：C57BL/6Smoc-Cdkn2aem2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190633

Cdkn2a(p19) gene knockout mouse model was established by knockout exon1 of Cdkn2a-p19ARF transcript (Cdkn2a-202 transcript).

Mice

Fasl-KO

Strain Name：C57BL/6Smoc-Faslem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190541

Exon 2-3 of Fasl gene was deleted to generate Fasl knockout mice.

Mice

Wnt10a-KO

Strain Name：C57BL/6Smoc-Wnt10Aem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190691

Exon 2 of Wnt10a gene was deleted to generate Wnt10a knockout mice.

Mice

Anxa1-KO

Strain Name：C57BL/6Smoc-Anxa1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200681

Exon 4 of Anxa1 gene was deleted to generate Anxa1 knockout mice.

Mice

Ajuba-KO

Strain Name：C57BL/6Smoc-Ajubaem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190912

Ajuba-KO mice (Stock No.NM-KO-190912） carry a knockout allele derived from the targeted deletion of exon 1-8. While Ajuba-KO(2) mice (Stock No.NM-KO-210327）carrying the exon 3-4 deletion.

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