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Models

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Mice

Pfkp-KO

Strain Name：C57BL/6Smoc-Pfkpem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190555

Pde4d-KO mice (Stock No.NM-KO-190555） carry a knockout allele derived from the targeted deletion of exon 4.

Mice

Hif1a-Flox

Strain Name：C57BL/6Smoc-Hif1atm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-190065
Publications：1piece

These mice carry loxP sites flanking exon 2 of Hif1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Hif1a gene.

Mice

Wrn-KO

Strain Name：C57BL/6Smoc-Wrnem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190902

Exon 5-8 of Wrn gene was deleted to generate Wrn knockout mice.

Mice

Tcf7l2-Flox

Strain Name：C57BL/6Smoc-Tcf7l2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200141

These mice carry loxP sites flanking exon 1-3 of Tcf7l2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tcf7l2 gene.

Mice

R26-CAG-LSL-hREST-IRES-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-LSL-REST-IRES-tdTomato-WPRE-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200051

These mice harbor a CAG-LSL-REST-IRES-tdTomato-WPRE-polyA cassette in the Rosa26 locus generated by homologous recombination.

Mice

Abi3bp-Flox

Strain Name：B6;129S-Abi3bptm1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-00009

An frt-neo-frt cassette was inserted before exon 4. And these mice possess loxP sites on either side of exon 4. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Ptpn2-Flox

Strain Name：C57BL/6Smoc-Ptpn2em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200049

These mice carry loxP sites flanking exon 3 of Ptpn2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ptpn2 gene.

Mice

Ptf1a-CreERT2

Strain Name：C57BL/6Smoc-Ptf1aem1(CreERT2-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200118
Validation Data：Presence

A CreERT2-WPRE-pA expression cassette was knocked into the Ptf1a gene start codon site.

Mice

Adamts1-KO

Strain Name：C57BL/6Smoc-Adamts1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200624

Adamts1-KO mice (Stock No.NM-KO-200624） carry a knockout allele derived from the targeted deletion of exon 5-7. While Adamts1-KO(2) mice (Stock No.NM-KO-2115470）mice carrying the exon 2 deletion.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001
Validation Data：Presence

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

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