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Models

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Mice

hIL4

Strain Name：C57BL/6Smoc-Il4tm3(hIL4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190071
Validation Data：Presence

The endogenous mouse Il4 gene was completely or partially replaced by human IL4 gene via ESC targeting.

Mice

Fcgr2b-Fcgr3-Fcgr4-KO/hPD-1/hCTLA-4

Strain Name：C57BL/6Smoc-Fcgr2bem1Fcgr3em1Fcgr4em1Pdcd1em1(hPDCD1)Ctla4em1(hCTLA4)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-220070

The Fcgr2b-Fcgr3-Fcgr4-KO/hPD-1/hCTLA4 mouse model was obtained by deleting sequences from upstream of Fcgr3 gene to the 3'UTR of Fcgr2b gene in the hPD-1/hCTLA4(NM-HU-00079) mouse.

Mice

hLAIR1

Strain Name：C57BL/6Smoc-Lair1tm2(LAIR1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000011

The endogenous mouse Lair1 gene was replaced by human LAIR1 gene .

Mice

hPD-L1/hSIRPA(2)

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd274tm1(hCD274)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000099

hPD-L1(NM-HU-00062) was crossed with hSIRPA(2)(NM-HU-18015) to generate hPD-L1/hSIRPA(2).

Mice

hPD-1/hCD27(2)

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd27tm2(hCD27)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000096

hPD-1(NM-HU-00015) was crossed with hCD27(2)(NM-HU-190035) to generate hPD-1/hCD27(2).

Mice

hIL6

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18017

This IL6 humanized mouse model was established by replacing the mouse Il6 gene coding exon1-5 and introns with the human IL6 corresponding sequence by homologous recombination via ES cell targeting.

Mice

Becn1-KO

Strain Name：C57BL/6Smoc-Becn1em2Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18028

Exon3 of Becn1 gene were deleted to generate Becn1 knockout mice.

Mice

Ambra1-Flox

Strain Name：C57BL/6Smoc-Ambra1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200059

These mice carry loxP sites flanking exon4 of Ambra1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ambra1 gene.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039
Validation Data：Presence  |  Publications：2piece

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

R26-CAG-LSL-hWNT1

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-WNT1-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190128

These mice harbor a SA-Frt-2xpA-CAG-Frt-LSL-WNT1-IRES-Luc-2A-tdTomato-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

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