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Models

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Mice

Cdk2-KO

Strain Name：C57BL/6Smoc-Cdk2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190052

This Cdk2 knockout mouse model was generated by knocking out the exon 2-3 region of the Cdk2 .

Mice

Ccne2-KO

Strain Name：C57BL/6Smoc-Ccne2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190932

Exon 6-7 of Ccne2 gene was deleted to generate Ccne2 knockout mice.

Mice

Ncoa3-Flox

Strain Name：C57BL/6Smoc-Ncoa3tm1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-190033

These mice carry loxP sites flanking exon6 of Ncoa3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ncoa3 gene.

Mice

Trp53-Flox

Strain Name：C57BL/6Smoc-Trp53tm2(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18005

These Trp53 flox mice possess loxP sites flanking exons 5-7 via ESC targeting. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

Cdkn2a-Flox(p19-Flox)

Strain Name：C57BL/6Smoc-Cdkn2aem2(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200151

These mice carry loxP sites flanking exon 1 of Cdkn2a-p19ARF transcript.

Mice

Msh2-KO

Strain Name：C57BL/6Smoc-Msh2em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 2 of Msh2 gene was deleted to generate Msh2 knockout mice.

Mice

Cav1-KO

Strain Name：C57BL/6Smoc-Cav1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190930

Exon 3 of Cav1 gene was deleted to generate Cav1 knockout mice.

Mice

Pten-KO

Strain Name：C57BL/6Smoc-Ptenem3Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18002

Exon5 of Pten gene was deleted to generate Pten knockout mice.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

Tgfbr2-Flox

Strain Name：C57BL/6Smoc-Tgfbr2tm1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-200026

These mice carry loxP sites flanking exon 3 of Tgfbr2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tgfbr2 gene.While Tgfbr2-Flox(2)(Stock No.NM-CKO-200228)mice carrying the loxP sites flanking exon 4 of Tgfbr2 gene.

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