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Models

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Mice

hIL2

Strain Name：C57BL/6Smoc-Il2tm3(hIL2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190048
Validation Data：Presence

The endogenous mouse Il2 gene was replaced by human IL2 gene.

Mice

hIL5/hIL5R(3)

Strain Name：C57BL/6Smoc-Il5tm3(hIL5)Il5ratm3(hIL5RA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220011
Validation Data：Presence

The endogenous mouse Il5 and Il5ra genes was replaced by human IL5 and IL5ra genes. While hIL5/hIL5R(Stock No.NM-HU-2000101) mice and hIL5/hIL5R(2)(Stock No.NM-HU-220010) function similarly to hIL5/hIL5R(3) mice, for more detailed information please contact our technical advisor.

Mice

Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA-4

Strain Name：C57BL/6Smoc-Fcgr2bem1Fcgr3em1Fcgr4em1Ctla4em1(hCTLA4)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-220069

The Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA4 mouse model was obtained by deleting all sequences from upstream of Fcgr3 gene to the 3'UTR of Fcgr2b gene in the hCTLA4(NM-HU-00014) mouse.

Mice

Fcgr2b-Fcgr3-Fcgr4-KO/hPD-1

Strain Name：C57BL/6Smoc-Fcgr2bem1Fcgr3em1Fcgr4em1Pdcd1em1(hPDCD1)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-220068

The Fcgr2b-Fcgr3-Fcgr4-KO/hPD-1 mouse model was obtained by deleting all sequences from upstream of Fcgr3 gene to the 3'UTR of Fcgr2b gene in the hPD-1(NM-HU-00015) mouse.

Mice

hPD-1/hVEGFR2

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Kdrtm2(hKDR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000098

hPD-1(NM-HU-00015) was crossed with hKDR(NM-HU-00098) to generate hPD-1/hKDR.

Mice

hPD-1/hSIGLEC15

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Siglec15tm1(hSIGLEC15)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000093

hPD-1(NM-HU-00015) was crossed with hSIGLEC15(NM-HU-190037) to generate hPD-1/hSIGLEC15.

Mice

hTIGIT/hPVR

Strain Name：C57BL/6Smoc-Tigittm1(hTIGIT)Pvrtm1(hPVR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000091
Validation Data：Presence

These mice are obtained through breeding of hTIGIT(NM-HU-00053) and hPVR(NM-HU-190012) mice.

Mice

hPD-1/hICOS(2)

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Icostm1(hICOS)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000100
Validation Data：Presence

hPD-1(NM-HU-00015) was crossed with hICOS(2)(NM-HU-190030) to generate hPD-1/hICOS(2).

Mice

hIL3/hCSF2

Strain Name：C57BL/6Smoc-Il3tm3(hIL3)Csf2tm3(hCSF2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190065
Validation Data：Presence

The endogenous mouse Il3 and Csf2 gene was replaced by human IL3 and CSF2 gene.

Mice

hSIRPA(2)/hCD47/hPD-L1

Strain Name：C57BL/6Smoc-Sirpatm2(hSIRPA)Cd274tm1(hCD274)Cd47tm1(hCD47)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000095

hPD-L1(NM-HU-00062),hCD47(NM-HU-00050) was crossed with hSIRPA(2) (NM-HU-18015) to generate hSIRPA(2)/hCD47/hPD-L1.

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