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Models

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Mice

hIL31

Strain Name：C57BL/6Smoc-Il31em2(IL31)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200008

The endogenous mouse Il31 gene was replaced by human IL31 gene.

Mice

hPD-1/hVISTA

Strain Name：C57BL/6Smoc-Visrem1(hVSIR)Pdcd1em1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000092

hPD-1(NM-HU-00015) was crossed with hSIRPA(2) (NM-HU-18015) to generate hPD-1/hVISTA.

Mice

hICOS(2)

Strain Name：C57BL/6Smoc-Icosem2(hICOS)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190030

The endogenous mouse Icos gene was replaced by human ICOS gene. While hICOS(Stock No.NM-HU-00052) mice function similarly to hICOS(2) mice,for more detailed information please contact our technical advisor.

Mice

hIL2

Strain Name：C57BL/6Smoc-Il2tm3(hIL2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190048

The endogenous mouse Il2 gene was replaced by human IL2 gene.

Mice

hIL2RG

Strain Name：C57BL/6Smoc-Il2rgem1(IL2RG)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200007

The endogenous mouse Il2rg gene was replaced by human IL2RG gene.

Mice

hCTLA-4(BALB/c)

Strain Name：BALB/cAnSmoc-Ctla4em1(hCTLA4) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190078

Obtained by backcrossing of NM-HU-00014，hCTLA-4 mice.

Mice

hOX40/hCTLA-4

Strain Name：C57BL/6Smoc-Tnfrsf4em3(hTNFRSF4)Ctla4em1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00105

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hPD-1/hVEGFR2

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Kdrtm2(hKDR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000098

hPD-1(NM-HU-00015) was crossed with hKDR(NM-HU-00098) to generate hPD-1/hKDR.

Mice

Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA-4

Strain Name：C57BL/6Smoc-Fcgr2bem1Fcgr3em1Fcgr4em1Ctla4em1(hCTLA4)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-220069

The Fcgr2b-Fcgr3-Fcgr4-KO/hCTLA4 mouse model was obtained by deleting all sequences from upstream of Fcgr3 gene to the 3'UTR of Fcgr2b gene in the hCTLA4(NM-HU-00014) mouse.

Mice

hIL3/hCSF2

Strain Name：C57BL/6Smoc-Il3tm3(hIL3)Csf2tm3(hCSF2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190065

The endogenous mouse Il3 and Csf2 gene was replaced by human IL3 and CSF2 gene.

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