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Models

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Mice

hPD-1(BALB/c)

Strain Name：BALB/cAnSmoc-Pdcd1em1(hPDCD1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190079

The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene .

Mice

hPD-L1/hSIGLEC15

Strain Name：C57BL/6Smoc-Cd274em1(hCD274)Siglec15em1(hSIGLEC15)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000103

hPD-L1(NM-HU-00062) was crossed with hSIGLEC15(NM-HU-190037) to generate hPD-L1/hSIGLEC15.

Mice

hIDO1

Strain Name：B6;129S-Ido1tm1(hIDO1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00061

The endogenous mouse Ido1 gene was replaced by human IDO1 gene.

Mice

hCTLA-4/4-1BB

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4) Tnfrsf9em1(hTNFRSF9) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18020

This CTLA4 and 4-1BB double knockin strain is established by crossing CTLA4-HU and 4-1BB-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hIL2RG

Strain Name：C57BL/6Smoc-Il2rgem1(IL2RG)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200007

The endogenous mouse Il2rg gene was replaced by human IL2RG gene.

Mice

hICOS

Strain Name：C57BL/6Smoc-Icosem1(hICOS)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00052

The endogenous mouse Icos gene was replaced by human ICOS gene. While hICOS(2)(Stock No.NM-HU-190030) mice function similarly to hICOS mice,for more detailed information please contact our technical advisor.

Mice

hPD-1/hVISTA

Strain Name：C57BL/6Smoc-Visrem1(hVSIR)Pdcd1em1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000092

hPD-1(NM-HU-00015) was crossed with hSIRPA(2) (NM-HU-18015) to generate hPD-1/hVISTA.

Mice

hIL13

Strain Name：C57BL/6Smoc-Il13em2(hIL13)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190069

The endogenous mouse Il13 gene was replaced by human IL13 gene.

Mice

hOX40/hCTLA-4

Strain Name：C57BL/6Smoc-Tnfrsf4em3(hTNFRSF4)Ctla4em1(hCTLA4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00105

These mice are OX40 and CTLA4 double knockin mouse models which can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCTLA-4(BALB/c)

Strain Name：BALB/cAnSmoc-Ctla4em1(hCTLA4) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190078

Obtained by backcrossing of NM-HU-00014，hCTLA-4 mice.

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