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Mice

hPD-1/hPD-L1/hPD-L2

Strain Name:C57BL/6Smoc-Pdcd1lg2em1(hPDCD1LG2)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190060

The endogenous mouse Pd-1/Pd-l1/Pdcd1lg2 gene was replaced by human PD-1/PD-L1/PDCD1LG2 gene.

Mice

hPD-L1/hSEMA4D

Strain Name:C57BL/6Smoc-Cd274em1(hPD-L1)Sema4dem1(hSemA4D)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190034

hPD-L1(NM-HU-00062) was crossed with hSEMA4D(NM-HU-00117) to generate hPD-L1/hSEMA4D.

Mice

hPD-L1(E3-4)

Strain Name:C57BL/6Smoc-Cd274em2(hPD-L1)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190039

Extracellular domain of mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene. While hPD-L1(Stock No.NM-HU-00062) mice function similarly to hPD-L1(2) mice,for more detailed information please contact our technical advisor.

Mice

hPD-1/hCD3E

Strain Name:C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd3eem1(hCD3E)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-18021

hPD-1(NM-HU-00015)was crossed with hCD3E(NM-HU-00114)to generate hPD-1/hCD3E。

Mice

hIL2RA

Strain Name:C57BL/6Smoc-Il2ratm1(hIL2RA)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190064

The endogenous mouse Il2ra gene was replaced by human IL2RA gene.

Mice

hPD-1/hSTING

Strain Name:C57BL/6Smoc-Tmem173tm1(hTMem173)Pdcd1em1(hPDCD1)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000104

hPD-1(NM-HU-00015) was crossed with hSTING(NM-HU-190036) to generate hPD-1/hSTING.

Mice

hCTLA-4/4-1BB

Strain Name:C57BL/6Smoc-Ctla4em1(hCTLA4) Tnfrsf9em1(hTNFRSF9) /Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-18020

This CTLA4 and 4-1BB double knockin strain is established by crossing CTLA4-HU and 4-1BB-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCD73(2)

Strain Name:C57BL/6Smoc-Nt5etm3(NT5E)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-200009

The endogenous mouse Nt5e gene was replaced by human NT5E gene.

Mice

hIL4/hIL4R

Strain Name:C57BL/6Smoc-Il4tm3(hIL4)Il4ratm1(hIL4R)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-2000106

These mice are obtained through breeding of two single gene humanized mice.

Mice

hTLR2

Strain Name:C57BL/6Smoc-Tlr2em2(hTLR2)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190066

The endogenous mouse Tlr2 gene was replaced by human TLR2 gene.

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