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Mice

hPD-1/hOX40

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Tnfrsf4em3(hTNFRSF4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00108

hPD-1（NM-HU-00015）was crossed with hOX40（NM-HU-00041）to generate hPD-1/hOX40.

Mice

hPD-L1/hOX40

Strain Name：C57BL/6Smoc-Cd274em1(hPD-L1)Tnfrsf4em1(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00111

hPD-L1（NM-HU-00062）was crossed with hOX40（NM-HU-00041）to generate hPD-L1/hOX40.

Mice

hCD80

Strain Name：C57BL/6Smoc-Cd80em1(hCD80) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00074

The endogenous mouse Cd80 gene was replaced by human CD80 gene .

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-hFcRn)Fcgrtem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

hOX40(2)

Strain Name：C57BL/6Smoc-Tnfrsf4em3(hTNFRSF4) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00078

The exon1-5 and partial exon6 of endogenous mouse Tnfrsf4(Ox40) gene was replaced by the corresponding region of human TNFRSF4(OX40) gene. While hOX40(Stock No.NM-HU-00041) mice function similarly to hOX40(2) mice,for more detailed information please contact our technical advisor.

Mice

hPD-1/hCTLA-4

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Ctla4em1(hCTLA4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00079

hPD-1(NM-HU-00015) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice

Mice

hPD-1/hPD-L1/hIDO1

Strain Name：C57BL/6Smoc-Ido1tm1(hIDO1)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-00120

hPD-1(NM-HU-00015),hPD-L1(NM-HU-00062) were crossed with hIDO1(NM-HU-00061) to generate hPD-1/hPD-L1/hIDO1.

Mice

Casp8-Flox

Strain Name：C57BL/6Smoc-Casp8em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-190003

These Casp8 flox mice possess loxP sites flanking exons 4. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

R26-CAG-LSL-hHER2-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-2xpolyA-CAG-LSL-HER2-luciferase-EGFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190008

A SA-2xpolyA-CAG-LSL-HER2-IRES-Luciferase-2A-EGFP-WPRE-polyA cassette was inserted at the Rosa26 locus. When bred to a strain expressing Cre recombinase under control of various tissue specific promoters, Cre recombination deletes the LSL cassette and allows the expression of the HER2 protein.

Mice

H11-CAG-LSL-Mycn-IRES-EGFP

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-HAtag-Mycn-IRES-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190084

These mice harbor a CAG-LSL-HA tag-Mycn-IRES-EGFP cassette in the lgs2 locus generated by homologous recombination.

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