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Cdx2-IRES-FLP

Strain Name：C57BL/6Smoc-Cdx2^{em1(IRES-FLP-Wpre-pA)Smoc}
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200307

IRES-FLP-Wpre-pA expression cassette was knocked into the Cdx2 gene stop codon site.

Cdx2-Flox

Strain Name：C57BL/6Smoc-Cdx2^{tm1(flox)Smoc}
Strain State：Repository Live | Cat. NO.：NM-CKO-200036

These mice carry loxP sites flanking exon 2 of Cdx2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cdx2 gene.

Cdx1-Flox

Strain Name：C57BL/6Smoc-Cdx1^{em1(flox)Smoc}
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Cdx1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cdx1 gene.

Cdx1-KO

Strain Name：C57BL/6Smoc-Cdx1^em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 1 of Cdx1 gene was deleted to generate Cdx1 knockout mice.

Cdx4-Flox

Strain Name：C57BL/6Smoc-Cdx4^{em1(flox)Smoc}
Strain State：Developing | Cat. NO.：TBD

These mice carry loxP sites flanking target exons of Cdx4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Cdx4 gene.

Cdx4-KO

Strain Name：C57BL/6Smoc-Cdx4^em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 1 of Cdx4 gene was deleted to generate Cdx4 knockout mice.

An essential role for DNA methyltransferase 3a in melanoma tumorigenesis

Model Organisms：小鼠 Product & Service：- Research field：Cancer

黑色素瘤 CDX模型

Mouse models for cancer research

Tumor bearing Mouse DEN model PDX model CDX model

Shanghai Model Organisms Center provides multiple types of tumor-bearing mouse models for cancer research and drug efficacy testing, including cell line-derived xenograft model (CDX) and patient-derived xenograft model (PDX). While PDX models better reflect the heterogeneity and diversity of human cancers, CDX models allow researchers to advance their pre-clinical drug development in a cost- and time-efficient manner.

Cancer Model

research on cancer cancer model mouse models of cancer

The laboratory mouse is widely considered as a valid and affordable model organism for studying human disease. Mouse models of cancer not only enable researchers to understand the genetic basis of tumor development in complicated and dynamic physiological systems, but also serve as irreplaceable tools for developing and testing new therapies.  Shanghai Model Organisms Center offers a variety of mouse models of cancer to meet the needs of both academic and industry partners.

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