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Models

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Mice

H11-CAG-RSR-EYFP

Strain Name：C57BL/6Smoc-Igs2em1(CAG-RSR-EYFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18056

A CAG-ROX-STOP-ROX-EYFP-V5tag-polyA conditional expression cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) . This strain of mice can be used to mate with mice expressing the Dre recombinase. After exposure to Dre recombinase, expression of ellow fluorescent protein and V5 tag is observed for cell tracking.

Mice

Pdcd1-DTR-2A-tdTomato

Strain Name：C57BL/6Smoc-Pdcd1em1(DTR-2A-tdTomato-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200225

A DTR-2A-tdTomato-WPRE-pA expression cassette was knocked into the Pdcd1 gene start codon site.

Mice

Rag2-KO

Strain Name：C57BL/6Smoc-Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190429

Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.

Mice

Upk3a-2A-GFPCre

Strain Name：C57BL/6Smoc-Upk3aem1(2A-EGFP-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-210003

2A-EGFP-Cre expression cassette was knocked into the Upk3a gene .

Mice

hCD19/hCD3E

Strain Name：C57BL/6Smoc-Cd19em1(hCD19)Cd3eem1(hCD3E)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190027

This CD19 and CD3E double knockin strain is established by crossing CD19-HU and CD3E-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

H11-CAG-EGFP

Strain Name：C57BL/6Smoc-Igs2 em1(CAG-EGFP-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00066

These mice harbor a CAG promoter-driven EGFP report gene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination.

Mice

hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00100

hPD-1(NM-HU-00015) was crossed with hPD-L1(NM-HU-00062)to generate hPD-1/hPD-L1 mice

Mice

Batf3-KO

Strain Name：C57BL/6Smoc-Batf3em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190447

exon 1-2 of Batf3 gene was deleted to generate Batf3 knockout mice.

Mice

hOX40

Strain Name：C57BL/6Smoc-Tnfrsf4em1(hTNFRSF4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00041

The endogenous mouse Tnfrsf4(Ox40) gene was replaced by human TNFRSF4(OX40) gene. While hOX40(2)(Stock No.NM-HU-00078) mice function similarly to hOX40 mice,for more detailed information please contact our technical advisor.

Mice

hCD24/hSIGLEC10

Strain Name：C57BL/6Smoc-Cd24atm1(hCD24)Siglecgtm1(hSIGLEC10)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210367

hCD24(NM-HU-2000060) was crossed with hSIGLEC10(NM-HU-2000061）to generate hCD24/hSIGLEC10 mice.

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