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Models

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Mice

hTIGIT

Strain Name：C57BL/6Smoc-Tigitem1(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00053

The endogenous mouse Tigit gene was replaced by human TIGIT gene. While hTIGIT(3)(Stock No.NM-HU-200244) mice function similarly to hTIGIT mice,for more detailed information please contact our technical advisor.

Mice

hB7H4

Strain Name：C57BL/6Smoc-Vtcn1em1(hVTCN1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190004

This VTCN1 humanized mouse model was established by replacing the mouse Vtcn1 gene with the human VTCN1. While hB7H4(2)(Stock No.NM-HU-190075) mice function similarly to hB7H4 mice,for more detailed information please contact our technical advisor.

Mice

hBTLA(2)

Strain Name：C57BL/6Smoc-Btlaem2(hBTLA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190040

Extracellular domain of mouse Btla gene was replaced by human BTLA gene. While hBTLA mice(Stock No.NM-HU-18014）have been pulled from shelves for some reasons.

Mice

Rag2/IL2rg-KO/hVEGFR2

Strain Name：C57BL/6Smoc-Il2rgem1Kdrtm2(hKDR)Rag2em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220087

IL2rg-KO (NM-KO-210098) mice were crossed with Rag2-KO/hKDR (NM-HU-200280) mice to generate Rag2/IL2rg-KO/hKDR mouse models.

Mice

Zbtb46-2A-CreERT2

Strain Name：C57BL/6Smoc-Zbtb46em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18021

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Zbtb46 gene via homologous recombination to establish a tamoxifen inducible Zbtb46-CreERT2 tool stain. This strain can be used to knockout target gene in Zbtb46+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

hCTLA-4

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4) Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00014

The endogenous mouse Ctal4 gene was replaced by human CTLA4 gene. While hCTLA4(2)(Stock No.NM-HU-190038) mice function similarly to hCTLA4 mice,for more detailed information please contact our technical advisor.

Mice

Procr-CreERT2-2A-tdTomato

Strain Name：C57BL/6Smoc-Procrem5(CreERT2-P2A-tdtomato-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200227

A CreERT2-P2A-tdtomato-Wpre-pA expression cassette was knocked into the Procr gene start codon site.

Mice

hCD24

Strain Name：C57BL/6Smoc-Cd24atm1(hCD24)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000060

The endogenous mouse Cd24a gene was replaced by human CD24 gene. While hCD24(2)(Stock No.NM-HU-215025) mice function similarly to hCD24 mice, for more detailed information please contact our technical advisor.

Mice

Apoe-KO(2)

Strain Name：C57BL/6Smoc-Apoeem5Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190565

Apoe-KO(2) mice (Stock No.NM-KO-190565) carry a knockout allele derived from the targeted deletion of exon 2-4. While Apoe-KO mice (Stock No.NM-KO-00033) have been pulled from shelves for some reasons.

Mice

H11-CAG-RSR-EYFP

Strain Name：C57BL/6Smoc-Igs2em1(CAG-RSR-EYFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18056

A CAG-ROX-STOP-ROX-EYFP-V5tag-polyA conditional expression cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) . This strain of mice can be used to mate with mice expressing the Dre recombinase. After exposure to Dre recombinase, expression of ellow fluorescent protein and V5 tag is observed for cell tracking.

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