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Models

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Mice

Sox10-KO

Strain Name：C57BL/6Smoc-Sox10em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200645

Exon 4-5 of Sox10 gene was deleted to generate Sox10 knockout mice.

Mice

hCD3EDG/hCD28

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd28em2(hCD28) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220113

hCD3EDG(NM-HU-220120) mice were crossed with hCD28(NM-HU-190011) to generate hCD3EDG/hCD28 mouse

Mice

hTIGIT/hPVR

Strain Name：C57BL/6Smoc-Tigitem1(hTIGIT)Pvrem1(hPVR)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000091

These mice are obtained through breeding of two single gene humanized mice.

Mice

Ctnnb1-Flox

Strain Name：C57BL/6Smoc-Ctnnb1em1(flox)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-CKO-200154

These mice carry loxP sites flanking exon 2-6 of Ctnnb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ctnnb1 gene.

Mice

Procr-DreERT2

Strain Name：C57BL/6Smoc-Procrem1(kozak-DreER-WPRE-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200201

A kozak-DreER-WPRE-pA expression cassette was knocked into the Procr gene start codon site.

Mice

Cdkl5-KO

Strain Name：C57BL/6Smoc-Cdkl5em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-2105744

Exon 6 of Cdkl5 gene was deleted to generate Cdkl5 knockout mice.

Mice

R26-SA-LSL-DTR-IRES-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-LSL-DTR-IRES-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210136

A SA-LSL-DTR-IRES-tdTomato expression cassette was knocked into via the Rosa26 locus.

Mice

hCD3EDG/hPD-L1

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd274em1(hPD-L1) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220112

hCD3EDG(NM-HU-220120) mice were crossed with hPD-L1(NM-HU-00062) mice to generate hCD3EDG/hPD-L1 mice

Mice

Aadacl2Fm1-KO

Strain Name：C57BL/6Smoc-Aadacl2Fm1em1Smoc
Strain State：Developing | Cat. NO.：TBD

Exon 5 of Aadacl2Fm1 gene was deleted to generate Aadacl2Fm1 knockout mice.

Mice

Prom1-CreERT2

Strain Name：C57BL/6Smoc-Prom1em1(CreERT2-PolyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200169

A CreERT2-PolyA expression cassette was knocked into the Prom1 gene start codon site. Prom1 encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. When these Prom1-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Prom1 expressing cells.

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