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Models

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Mice

Aldob-KO

Strain Name：C57BL/6Smoc-Aldobem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-200602

Exon 3-6 of Aldob gene was deleted to generate Aldob knockout mice.

Mice

Aadacl2fm1-Flox

Strain Name：C57BL/6Smoc-Aadacl2fm1em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-253840

These mice carry loxP sites flanking exon 5 of Aadacl2fm1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Aadacl2fm1 gene.

Mice

Mc4r-2A-Cre

Strain Name：C57BL/6Smoc-Mc4rem1(T2A-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200220
Validation Data：Presence

A T2A-Cre expression cassette was knocked into the Mc4r gene stop codon site.

Mice

Prox1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Prox1em1(IRES-CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200119
Validation Data：Presence

A IRES-CreERT2-pA expression cassette was knocked into the Prox1 gene stop codon site. Prox1 encodes a transcription factor (prospero-related homeobox 1) that is necessary for the formation and maintenance of lymphatic vessels. When Prox1-IRES-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in PROX1positive cells.

Mice

hIL11

Strain Name：C57BL/6Smoc-Il11tm1(hIL11)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204981

The endogenous mice Il11 gene was replaced by human IL11 gene.

Mice

Aadacl3-Flox

Strain Name：C57BL/6Smoc-Aadacl3em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-253851

These mice carry loxP sites flanking exon 2-3 of Aadacl3 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Aadacl3 gene.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001
Validation Data：Presence

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

Col1a1-TRE3G-dCas9-VPR-EGFP

Strain Name：C57BL/6Smoc-Col1a1em1(TRE3G-dCas9-VPR-eGFP-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-00123

These mice harbor a TRE3G-dCas9-VPR(VP64-p65-Rta)-eGFP-pA tetracycline-controlled transcriptional activation cassette in mouse Col1a1 loci. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

Mice

Abcg8-KO

Strain Name：C57BL/6Smoc-Abcg8em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-200906

Exon 3 of Abcg8 gene was deleted to generate Abcg8 knockout mice.

Mice

Abcb8-Flox

Strain Name：C57BL/6Smoc-Abcb8em1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-253536

These mice carry loxP sites flanking exon 3-6 of Abcb8 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Abcb8 gene.

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