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Models

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Mice

hIL7R

Strain Name：C57BL/6Smoc-Il7rtm1(hIL7R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210027
Validation Data：Presence

The endogenous mice Il7r gene was completely or partially replaced by human IL7R gene via ESC targeting.

Mice

Foxl1-2A-CreERT2

Strain Name：C57BL/6Smoc-Foxl1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00135
Validation Data：Presence

A 2A-CreERT2 coexpression cassette is inserted before the stop codon of mouse Foxl1 gene via homologous recombination to establish a Foxl1-CreERT2 recombinase tool stain. This strain can be used to knockout target gene inFoxl1+ cells after tamoxifen treatment when crossed with flox mice.

Mice

hTGFB1

Strain Name：C57BL/6Smoc-Tgfb1tm1(hTGFB1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200243

The endogenous mice Tgfb1 gene was replaced by human TGFB1 gene.

Mice

hHLA-DPB1*04: 01

Strain Name：C57BL/6Smoc-H2-Ab1tm1(hHLA-DPB1*04: 01)/Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-210011
Validation Data：Presence

The endogenous mice H2-Ab1 gene was replaced by human HLA-DPB1*04:01 gene.

Mice

App-KO

Strain Name：C57BL/6Smoc-Appem1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190444

exon 3 of App gene was deleted to generate App knockout mice.

Mice

hPSMA

Strain Name：C57BL/6Smoc-Folh1tm1(hPSMA-Wpre-PA)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200240
Validation Data：Presence

The endogenous mice Folh1 gene was replaced by human PSMA gene.

Mice

hCTLA-4/h4-1BB(2)

Strain Name：C57BL/6Smoc-Ctla4tm1(hCTLA4)Tnfrsf9tm2(TNFRSF9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210355

hCTLA4(NM-HU-00014) was crossed with h4-1BB(2)(NM-HU-190077）to generate hCTLA4/h4-1BB(2) mice.

Mice

hCD3E/hCD28

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E))Cd28tm2(hCD28)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210233

hCD3E(NM-HU-00114) was crossed with hCD28(NM-HU-190011) to generate hCD3E/hCD28 mice.

Mice

hCD3E/hCD38(2)

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E))Cd38tm2(hCD38)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210234

hCD3E(NM-HU-00114) was crossed with hCD38(2)(NM-HU-190059) to generate hCD3E/hCD38(2) mice.

Mice

Cd2-2A-CreERT2

Strain Name：C57BL/6Smoc-Cd2em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18017
Validation Data：Presence

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Cd2 gene via homologous recombination to establish a tamoxifen inducible Cd2-CreERT2 tool stain. This strain can be used to knockout target gene in T cells and B cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

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