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Models

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Mice

R26-CAG-LSL-hTM6SF2*E167K-EGFP

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200017

These mice harbor a SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA cassette in the Rosa26 locus generated by homologous recombination.

Mice

Axin2-2A-DreERT2

Strain Name：C57BL/6Smoc-Axin2em1(P2A-DreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200196

A P2A-DreERT2 expression cassette was knocked into the Axin2 gene stop codon site.

Mice

hPD-L1(E3-4)

Strain Name：C57BL/6Smoc-Cd274em2(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190039

Extracellular domain of mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene. While hPD-L1(Stock No.NM-HU-00062) mice function similarly to hPD-L1(2) mice,for more detailed information please contact our technical advisor.

Mice

Crbn-I391V/Rag2-KO

Strain Name：C57BL/6Smoc-Crbnem1(I391V)Rag2em2Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210398

Crbn-I391V(NM-KI-200331) was crossed with Rag2-KO(NM-KO-190429) to generate Crbn-I391V/Rag2-KO mice.

Mice

hPD-L1(2)/hCCR8

Strain Name：C57BL/6Smoc-Cd274em2(hPD-L1)Ccr8em1(hCCR8)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210401

hPD-1(2)(NM-HU-190039) was crossed with hCCR8(NM-HU-190053) to generate hPD-L1(2)/hCCR8 mice.

Mice

Aldh5a1-KO

Strain Name：C57BL/6Smoc-Aldh5a1em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-201238

Exon 3-7 of Aldh5a1 gene was deleted to generate Aldh5a1 knockout mice.

Mice

hCD2

Strain Name：C57BL/6Smoc-Cd2tm1(hCD2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-204986

The endogenous mice Cd2 gene was replaced by human CD2 gene.

Mice

hPD-1/hPD-L1/hTIM3

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Havcr2em1(hHAVCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200264

hTIM3（NM-HU-00054）,hPD-1（NM-HU-00015）,hPD-L1（NM-HU-00062）were crossed together to generate hPD-1/hPD-L1/hTIM3 mice

Mice

hCTLA-4/4-1BB

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4) Tnfrsf9em1(hTNFRSF9) /Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18020

This CTLA4 and 4-1BB double knockin strain is established by crossing CTLA4-HU and 4-1BB-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hIL2RA/hIL2RB/hIL2RG

Strain Name：C57BL/6Smoc-Il2ratm1(hIL2RA)Il2rgem1(IL2RG)Il2rbtm1(hIL2RB)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210414

hIL2RA(NM-HU-190064) was crossed with hIL2RG/hILRB(NM-HU-210354) to generate hIL2RA/hIL2RB/hIL2RG mice.

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