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Models

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Mice

hFCGR2B/h4-1BB(2)

Strain Name：C57BL/6Smoc-Fcgr2bem2(FCGR2B)Tnfrsf9tm2(TNFRSF9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210352

hFCGR2B(NM-HU-2000010) was crossed with h4-1BB (NM-HU-190077) to generate hFCGR2B/h4-1BB mice.

Mice

hICOS/hICOSL

Strain Name：C57BL/6Smoc-Icoslem1(hICOSLG) Icosem1(hICOS)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18018

This ICOS and ICOSL double knockin strain is established by crossing ICOS-HU and ICOSL-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

Apc-L850X

Strain Name：C57BL/6Smoc-Apcem1(L850X)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200001

Familial adenomatous polyposis (FAP) is a heritable condition in which affected individuals develop benign intestinal polyps. Often, polyps progress to colorectal carcinomas later in life. The mutation of C57BL/6-Apcem1(L850X)Smoc(NM-KI-200001) strain of SMOC refers to the ApcMin model (Jax: 002020 ), a useful model to study intestinal adenomas. The C57BL/6-Apcem1(L850X)Smoc strain is highly susceptible to spontaneous intestinal adenoma formation and can be used as a research model for human FAP. These mice carry a p.L850X mutation of Apc gene.

Mice

hPD-L1/hCTLA-4

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4)Cd274em1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00102

hPD-L1(NM-HU-00062) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice

Mice

hOX40L

Strain Name：C57BL/6Smoc-Tnfsf4em1(hTNFSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00070

The endogenous mouse Tnfsf gene was replaced by human TNFSF4（OX-40L） gene . While hOX40L(2)(Stock No.NM-HU-200005) mice function similarly to hOX40L mice,for more detailed information please contact our technical advisor.

Mice

Lyz2-2A-CreERT2

Strain Name：C57BL/6Smoc-Lyz2em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18018

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Lyz2 gene via homologous recombination to establish a tamoxifen inducible Lyz2-CreERT2 tool stain. This strain can be used to knockout target gene in Lyz2+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

hTNFRSF10B

Strain Name：C57BL/6Smoc-Tnfrsf10bem1(hTNFRSF10B)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210005

The endogenous mice Tnfrsf10B gene was replaced by human TNFRSF10B gene

Mice

hIL4/hIL4R

Strain Name：C57BL/6Smoc-Il4tm3(hIL4)Il4ratm1(hIL4R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000106

These mice are obtained through breeding of two single gene humanized mice.

Mice

Abcg2-KO

Strain Name：C57BL/6Smoc-Abcg2em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18013

Exon3-5 of Abcg2 gene were deleted to generate Abcg2 knockout mice.

Mice

hICOSL

Strain Name：C57BL/6Smoc-Icoslem1(hICOSLG) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00095

The endogenous mouse Icosl gene was replaced by human ICOSL gene . While hICOSL(2)(Stock No.NM-HU-2000068) mice function similarly to hICOSL mice,for more detailed information please contact our technical advisor.

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