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Models

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Mice

hCD3EDG/hEpCAM

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Epcamtm1(hEPCAM)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220123
Validation Data：Presence

hCD3EDG(NM-HU-220120) mice were crossed with hEpCAM(NM-HU-210032) mice to generate hCD3EDG/hEpCAM mice.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6ratm1(hIL6R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025
Validation Data：Presence

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCD3EDG/hCD19

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd19em1(hCD19) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220109
Validation Data：Presence

hCD3EDG(NM-HU-220120) mice were crossed with hCD19(NM-HU-00110) mice to generate hCD3EDG/hCD19 mice.

Mice

Pdcd1-DTR-2A-tdTomato

Strain Name：C57BL/6Smoc-Pdcd1em1(DTR-2A-tdTomato-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200225

A DTR-2A-tdTomato-WPRE-pA expression cassette was knocked into the Pdcd1 gene start codon site.

Mice

Agxt-KO

Strain Name：C57BL/6Smoc-Agxtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-210152

Exon 3-8 of Agxt gene was deleted to generate Agxt knockout mice.

Mice

hCCR8(2)/hTIGIT

Strain Name：C57BL/6Smoc-Tigittm3(hTIGIT)Ccr8tm3(hCCR8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220073

hTIGIT(NM-HU-200244) mice were crossed with hCCR8(2) (NM-HU-2000054) mice to generate hTIGIT/hCCR8 mice．

Mice

Zmpste24-KO

Strain Name：C57BL/6Smoc-Zmpste24em1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18011

Exon4-6 of Zmpste24 gene were deleted to generate Zmpste24 knockout mice.

Mice

R26-CAG-LSL-zsGreen

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-zsGreen)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200045
Validation Data：Presence

These mice harbor a CAG-LSL-zsGreen-polyA cassette in the Rosa26 locus generated by homologous recombination.

Mice

hTLR8/hPD-1

Strain Name：C57BL/6Smoc-Tlr8tm2(TLR8)Pdcd1tm1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200276

hTLR8(NM-HU-190044) was crossed with hPD-1(NM-HU-00015)to generate hTLR8/hPD-1 mice

Mice

hTNFR2/hPD-1

Strain Name：C57BL/6Smoc-Tnfrsf1btm2(hTNFRSF1B)Pdcd1tm1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210407

hTNFRSF1B(NM-HU-190010) was crossed with hPD-1（NM-HU-00015）to generate hTNFRSF1B/hPD-1 mice

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