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Models

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Mice

hEGFR

Strain Name：C57BL/6Smoc-Egfrtm1(hEGFR)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200227

The endogenous mice Egfr gene was replaced by human EGFR gene. While hEGFR(2)(Stock No.NM-HU-200232) mice have been pulled from shelves for some reasons.

Mice

Zbtb46-IRES-Cre

Strain Name：C57BL/6Smoc-Zbtb46em1(IRES-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200096

A  IRES-iCre expression cassette was knocked into the Zbtb46 gene stop codon site. This strain carries a significant risk of reproductive system leakage. Avoid using homozygotes and female Cre mice. It is recommended to use male mice, as they have a lower probability of leakage. After mating, offspring should be genotyped and promptly checked for any occurrence of reproductive leakage.

Mice

hPD-1/hCTLA-4

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Ctla4em1(hCTLA4)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00079

hPD-1(NM-HU-00015) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice

Mice

Ly6g-2A-CreERT2

Strain Name：C57BL/6Smoc-Ly6gem3(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200218

A 2A-CreERT2 expression cassette was knocked into the Ly6g gene start codon site.

Mice

Aire-KO

Strain Name：C57BL/6Smoc-Aireem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-2112347

Exon 8 of Aire gene was deleted to generate Aire knockout mice.

Mice

hCD3E/hSDC1

Strain Name：C57BL/6Smoc-Cd3eem1(hCD3E)Sdc1em1(hSDC1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220021

hCD3E(NM-HU-00114) was crossed with hSDC1(NM-HU-2000026) to generate hCD3E/hSDC1 mice.

Mice

hCD3E/hCD38(2)

Strain Name：C57BL/6Smoc-Cd3eem1(hCD3E))Cd38em2(hCD38)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210234

hCD3E(NM-HU-00114) was crossed with hCD38(2)(NM-HU-190059) to generate hCD3E/hCD38(2) mice.

Mice

hCTLA-4/h4-1BB(2)

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4)Tnfrsf9tm2(TNFRSF9)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210355

hCTLA4(NM-HU-00014) was crossed with h4-1BB(2)(NM-HU-190077）to generate hCTLA4/h4-1BB(2) mice.

Mice

hCD3E/hLAG3

Strain Name：C57BL/6Smoc-Cd3eem1(hCD3E)Lag3tm1(hLAG3)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220027

hCD3E(NM-HU-00114) was crossed with hLAG3( NM-HU-00049) to generate hCD3E/hLAG3 mice.

Mice

hFAS

Strain Name：C57BL/6Smoc-Fasem1(hTNFRSF6)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210007

The endogenous mice Fas gene was replaced by human FAS gene.

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