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Mice

Ifngr1/Ifnar1-KO

Strain Name：C57BL/6Smoc-Ifngr1em1Ifnar1em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190425
Validation Data：Presence

This Ifngr1 and Ifnar1 double knockout strain is established by crossing Ifngr1-KO and Ifnar1-KO mice together.

Mice

a-IRES-Cre

Strain Name：C57BL/6Smoc-atm1(Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200027
Publications：1piece

A IRES-Cre expression cassette was knocked into the a gene stop codon site via ESC targeting. Male mice with a germline Cre leak expression condition, please use female mice and flox mice for breeding crosses. References are available, please see the website for details.

Mice

hCD3E(2)

Strain Name：C57BL/6Smoc-Cd3etm2(hCD3E)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210023

The endogenous mice Cd3e gene was replaced by human CD3E gene. While hCD3E(Stock No.NM-HU-00114) mice function similarly to hCD3E(2) mice,for more detailed information please contact our technical advisor.

Mice

hFCRN(2)

Strain Name：C57BL/6Smoc-Fcgrttm2(hFCGRT)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190070
Validation Data：Presence  |  Publications：1piece

The endogenous mouse Fcgrt gene was replaced by human FCGRT gene.While hFCRN(Stock No.NM-HU-00109) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN(2) mice,for more detailed information please contact our technical advisor.

Mice

Upk3a-2A-GFPCre

Strain Name：C57BL/6Smoc-Upk3aem1(2A-EGFP-Cre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-210003

2A-EGFP-Cre expression cassette was knocked into the Upk3a gene .

Mice

Foxp3-IRES-tdTomato-2A-Cre

Strain Name：C57BL/6Smoc-Foxp3em3(IRES-tdTomato-2A-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190119
Validation Data：Presence

A IRES-tdTomato-2A-Cre expression cassette was knocked into the Foxp3 gene stop codon site. This strain is useful in studying regulatory T cell in autoimmunity, especially in type 1 diabetes.

Mice

H11-CAG-RSR-EYFP

Strain Name：C57BL/6Smoc-Igs2em1(CAG-RSR-EYFP)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-18056

A CAG-ROX-STOP-ROX-EYFP-V5tag-polyA conditional expression cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) . This strain of mice can be used to mate with mice expressing the Dre recombinase. After exposure to Dre recombinase, expression of ellow fluorescent protein and V5 tag is observed for cell tracking.

Mice

Abcc8-KO(2)

Strain Name：C57BL/6Smoc-Abcc8em2Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-225150

exon 8-16 of Abcc8 gene was deleted to generate Abcc8 knockout mice.

Mice

Gad2-IRES-Cre

Strain Name：C57BL/6Smoc-Gad2em1(IRES-iCre-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200078
Validation Data：Presence

A IRES-iCre-pA expression cassette was knocked into the Gad2 gene stop codon site.

Mice

CAG-LSL-dCas9-SPH-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00025
Publications：1piece

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher). *This strain is a client-donated line. The donor's publication indicates that fluorescence was observed by immunofluorescence. The JAX description of this strain also explicitly states that fluorescence cannot be directly observed.

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