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Models

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Mice

Cd2-2A-CreERT2

Strain Name:C57BL/6Smoc-Cd2em1(2A-CreERT2-WPRE-pA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-18017

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Cd2 gene via homologous recombination to establish a tamoxifen inducible Cd2-CreERT2 tool stain. This strain can be used to knockout target gene in T cells and B cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

hIL6/hIL6R

Strain Name:C57BL/6Smoc-Il6tm1(hIL6)Il6raem1(hIL6R)/Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-190025

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hTNFR2/hPD-1

Strain Name:C57BL/6Smoc-Tnfrsf1bem2(hTNFRSF1B)Pdcd1em1(hPDCD1) /Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210407

hTNFRSF1B(NM-HU-190010) was crossed with hPD-1(NM-HU-00015)to generate hTNFRSF1B/hPD-1 mice

Mice

Akt2-KO

Strain Name:C57BL/6Smoc-Akt2em1Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KO-190742

Exon 3-4 of Akt2 gene was deleted to generate Akt2 knockout mice.

Mice

hTIGIT/hTNFR2

Strain Name:C57BL/6Smoc-Tigittm3(hTIGIT)Tnfrsf1bem2(hTNFRSF1B)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210371

hTIGIT(3)(NM-HU-200244) was crossed with hTNFRSF1B(NM-HU-190010)to generate hTIGIT(3)/hTNFRSF1B mice

Mice

A2m-Flox

Strain Name:C57BL/6Smoc-A2mem1(flox)Smoc
Strain State:Developing | Cat. NO.:TBD

These mice carry loxP sites flanking target exons of A2m gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A2m gene.

Mice

hSOST(2)

Strain Name:C57BL/6Smoc-Sostem1(hSOST)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-HU-215021

The endogenous mice Sost gene was replaced by human SOST gene. While hSOST(Stock No.NM-HU-200251) mice function similarly to hSOST(2) mice, for more detailed information please contact our technical advisor.

Mice

App-KO

Strain Name:C57BL/6Smoc-Appem1Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KO-190444

exon 3 of App gene was deleted to generate App knockout mice.

Mice

G6pc-Flox

Strain Name:C57BL/6Smoc-G6pcem1(flox)Smoc
Strain State:Repository Live | Cat. NO.:NM-CKO-200053

These mice carry loxP sites flanking exon 3 of G6pc gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of G6pc gene.

Mice

hPD-L1/hCD73(2)

Strain Name:C57BL/6Smoc-Cd274em1(hPD-L1)Nt5eem2(NT5E)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210356

hPD-L1(NM-HU-00062) was crossed with hCD73(2)(NM-HU-200009) to generate hPD-L1/hCD73(2) mice.

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