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Models

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Mice

Acan-IRES-CreERT2

Strain Name：C57BL/6Smoc-Acanem1(IRES-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200143
Validation Data：Presence

A IRES-CreERT2 expression cassette was knocked into the Acan gene stop codon site via CRISPR/Cas9 mediated recombination.

Mice

CAG-Dre-Tg

Strain Name：C57BL/6Smoc-Tg(CAG-Dre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-TG-00026

These transgenic mice carry Dre recombinase driven by CAG promoter.

Mice

hEPCAM

Strain Name：C57BL/6Smoc-Epcamtm1(hEPCAM)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210032
Validation Data：Presence

The endogenous mice Epcam gene was completely or partially replaced by human EPCAM gene via ESC targeting.

Mice

Aplnr-2A-DreERT2

Strain Name：C57BL/6Smoc-Aplnrem1(2A-DreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00132
Publications：1piece

A 2A-DreERT2-SV40polyA coexpression cassette is inserted befor the stop codon of mouse Aplnr gene via homologous recombination to establish a tamoxifen inducible Aplnr-DreERT2 tool stain. This strain can be used to knockout target gene in Aplnr+ cells after tamoxifen treatment when crossed with mice which carry rox sites flanking target gene.

Mice

hCD226

Strain Name：C57BL/6Smoc-Cd226tm(hCD226)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-215012
Validation Data：Presence

The endogenous mice Cd226 gene was replaced by human CD226 gene.

Mice

Ascl1-CreERT2

Strain Name：C57BL/6Smoc-Ascl1em1(CreERT2-Wpre-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200207
Validation Data：Presence

A CreERT2-Wpre-pA expression cassette was knocked into the Ascl1 gene start codon site.

Mice

hCD40/hCD40L

Strain Name：C57BL/6Smoc-CD40tm2(hCD40)Cd40lgtm1(hCD40L)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200268
Validation Data：Presence

hCD40（NM-HU-00076）was crossed with hCD40L（NM-HU-2000033）to generate hCD40/hCD40L mice

Mice

A2m-KO

Strain Name：C57BL/6Smoc-A2mem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-190549

Exon 4 of A2m gene was deleted to generate A2m knockout mice.

Mice

hPD-L1/hCD28

Strain Name：C57BL/6Smoc-Cd274tm1(hPD-L1)Cd28tm2(hCD28)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210019

hPD-L1(NM-HU-00062) was crossed with hCD28(NM-HU-190011) to generate hPD-L1/hCD28 mice

Mice

hCD19/hCD3E

Strain Name：C57BL/6Smoc-Cd19tm1(hCD19)Cd3etm1(hCD3E)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190027
Validation Data：Presence

This CD19 and CD3E double knockin strain is established by crossing CD19-HU and CD3E-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

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