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Models

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Mice

MHC Class II (I-A/I-E) -KO

Strain Name：C57BL/6Smoc-H2-Ab1em1H2-Aaem1 H2-Eb1em1H2-Eb2em1H2-Ea-ps em1 Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-18032

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

C57BL/6

Strain Name：C57BL/6Smoc
Strain State：Repository Live | Cat. NO.：SM-001

C57BL/6 mice have a high reproductive capacity, a long life span, and a low tumor susceptibility. Male mice are aggressive and fight frequently. Diet can cause obesity, type II diabetes, and atherosclerosis in these mice. The C57BL/6 mouse is the first to have its entire genome sequenced. It is the most extensively used inbred mouse strain as a genetic basis for congenic and mutant mice. It is also used in genetics, metabolism, immunology, neurology, behavioral research, pharmacodynamics, and medication safety evaluation.

Mice

Plp1-Flox

Strain Name：C57BL/6Smoc-Plp1em1(flox)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-CKO-200072

These mice carry loxP sites flanking exon 3 of Plp1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Plp1 gene.

Mice

hPD-L1

Strain Name：C57BL/6Smoc-Cd274em1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00062

The endogenous mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene . While hPD-L1(2)(Stock No.NM-HU-190039) mice function similarly to hPD-L1 mice,for more detailed information please contact our technical advisor.

Mice

R26-CAG-LSL-RSR-tdTomato-2A-DTR

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-RSR-tdTomato-2A-DTR)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190086

These mice harbor a CAG-LSL-RSR-tdTomato-2A-DTR cassette in the Rosa26 locus generated by homologous recombination.

Mice

hCD81/hOCLN

Strain Name：C57BL/6Smoc-Cd81em1(hCD81)Oclnem1(hOCLN)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000107

These mice are obtained through breeding of two single gene humanized mice.

Mice

h4-1BB(2)

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190077

The endogenous mouse Tnfrsf9 gene was replaced by human TNFRSF9(4-1BB) gene. While h4-1BB mice(Stock No.NM-HU-00099）have been pulled from shelves for some reasons.

Mice

Atp4b-IRES-CreERT2

Strain Name：C57BL/6Smoc-Atp4bem1(IRES-CreERT2-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210118

An IRES-CreERT2-WPRE-pA expression cassette was knocked into the Atp4b gene stop codon site. Besides, An IRES-CreERT2 expression cassette were knock into the Bhlha15 gene stop codon site to generate Atp4b-IRES-CreERT2(2)(Stock No. NM-KI-210119) mice.

Mice

Cd8a-IRES-DTRGFP/Cd8a-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Cd8aem2(IRES-DTREGFP)Cd8aem1(V5-IRES-luci-2A-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-210399

Cd8a-IRES-DTRGFP(NM-KI-190045) was crossed with Cd8a-IRES-Luc-2A-EGFP(NM-KI-18030) to generate Cd8a-IRES-DTRGFP/Cd8a-IRES-luc-2A-EGFP mice.

Mice

hCTLA-4/Cd8a-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4)Cd8aem1(V5-IRES-luc-2A-EGFP)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210374

hCTLA4(NM-HU-00014) was crossed with Cd8a-IRES-Akaluc-2A-EGFP(NM-KI-18030) to generate hCTLA4/Cd8a-IRES-Akaluc-2A-EGFP mice.

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