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Models

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Mice

MHC Class II (I-A/I-E) -KO

Strain Name:C57BL/6Smoc-H2-Ab1em1H2-Aaem1 H2-Eb1em1H2-Eb2em1H2-Ea-ps em1 Smoc
Strain State:Repository Live | Cat. NO.:NM-KO-18032
Validation Data:Presence

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.

Mice

hOX40/hOX40L(2)/hICOS

Strain Name:C57BL/6J-Tnfrsf4tm1(hTNFRSF4)Tnfsf4tm2(hTNFSF4)Icostm1(hICOS)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-252545

ICOS humanization was performed on the background of hOX40/hOX40L(2) mice using homologous recombination

Mice

HLA-B58.1/B2M

Strain Name:C57BL/6J-B2mtm1(hB2M-linker-HLA-B*5801/H2-D1)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-252700
Validation Data:Presence

The endogenous mouse B2m gene was replaced by human HLA-B gene.

Mice

HLA-B40.1/B2M

Strain Name:C57BL/6J-B2mtm1(hB2M-linker-HLA-B*4001/H2-D1)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-252699
Validation Data:Presence

The endogenous mouse B2m gene was replaced by human HLA-B gene.

Mice

HLA-B39.1/B2M

Strain Name:C57BL/6J-B2mtm1(hB2M-linker-HLA-B*3901/H2-D1)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-252702
Validation Data:Presence

The endogenous mouse B2m gene was replaced by human HLA-B gene.

Mice

HLA-B7.2/B2M

Strain Name:C57BL/6J-B2mtm1(hB2M-linker-HLA-B*0702/H2-D1)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-252701
Validation Data:Presence

The endogenous mouse B2m gene was replaced by human HLA-B gene.

Mice

hFCGR2A/hFCGR3A/hFCGR2C/hFCGR3B/hFCGR2B

Strain Name:C57BL/6J-Fcgr tm1(FCGR2A/FCGR3A/FCGR2C/FCGR3B/FCGR2B)Smoc
Strain State:Developing | Cat. NO.:NM-HU-252765

The endogenous mouse Fcgr gene was replaced by human FCGR2A/FCGR3A/FCGR2C/FCGR3B/FCGR2B gene.

Mice

hINHBC/hINHBE

Strain Name:C57BL/6J- Inhbc tm1(hINHBC )Inhbe tm1(hINHBE )Smoc
Strain State:Developing | Cat. NO.:NM-HU-252965

The endogenous mouse Inhbc/Inhbe gene was replaced by human INHBC gene.

Mice

HLA-A24.2/B2M(V1)

Strain Name:C57BL/6J-H2-D1tm1(hB2M-linker-HLA-A24.2)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-254020

The endogenous mouse H2-D1 gene was replaced by human HLA-A gene.

Mice

HLA-A11.1/B2M(V1)

Strain Name:C57BL/6J-H2-K1tm1(hB2M-linker-HLA-A*1101)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-254021

The endogenous mouse H2-K1 gene was replaced by human HLA-A gene.

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