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Models

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Mice

hCD3EDG/hEpCAM

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Epcamtm1(hEPCAM)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220123
Validation Data：Presence

hCD3EDG(NM-HU-220120) mice were crossed with hEpCAM(NM-HU-210032) mice to generate hCD3EDG/hEpCAM mice.

Mice

hIL6/hIL6R

Strain Name：C57BL/6Smoc-Il6tm1(hIL6)Il6ratm1(hIL6R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190025
Validation Data：Presence

This IL6 and IL6R double knockin strain is established by crossing IL6-HU and IL6R-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hCD3EDG/hCD19

Strain Name：C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd19em1(hCD19) /Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220109
Validation Data：Presence

hCD3EDG(NM-HU-220120) mice were crossed with hCD19(NM-HU-00110) mice to generate hCD3EDG/hCD19 mice.

Mice

Il12b-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il12bem1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00025

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon.

Mice

hIL7

Strain Name：C57BL/6Smoc-Il7tm1(hIL7)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190031
Validation Data：Presence

The endogenous mouse Il7 gene was replaced by human IL7 gene.

Mice

hCD80

Strain Name：C57BL/6Smoc-Cd80tm1(hCD80) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00074
Validation Data：Presence

The endogenous mouse Cd80 gene was replaced by human CD80 gene .

Mice

Pdcd1-DTR-2A-tdTomato

Strain Name：C57BL/6Smoc-Pdcd1em1(DTR-2A-tdTomato-WPRE-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200225

A DTR-2A-tdTomato-WPRE-pA expression cassette was knocked into the Pdcd1 gene start codon site.

Mice

Agxt-KO

Strain Name：C57BL/6Smoc-Agxtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-210152

Exon 3-8 of Agxt gene was deleted to generate Agxt knockout mice.

Mice

hCLEC4C

Strain Name：C57BL/6Smoc-Dppa3tm1(hCLEC4C)Smoc
Strain State：Developing | Cat. NO.：NM-HU-225073

The human CLEC4C gene was knocked in the close location of the Dppa3 gene.

Mice

hCCR8(2)/hTIGIT

Strain Name：C57BL/6Smoc-Tigittm3(hTIGIT)Ccr8tm3(hCCR8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220073

hTIGIT(NM-HU-200244) mice were crossed with hCCR8(2) (NM-HU-2000054) mice to generate hTIGIT/hCCR8 mice．

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