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Mice

Pten-Flox

Strain Name：C57BL/6Smoc-Ptenem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18004
Publications：1piece

These Pten flox mice possess loxP sites flanking exons 5 via CRISPR/Cas mediated recombination. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

hTLR7

Strain Name：C57BL/6Smoc-Tlr7tm1(hTLR7)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18027
Validation Data：Presence

The endogenous mouse Tlr7 gene was replaced by humanTLR7 gene.

Mice

hCD27(2)/hFCGR2B

Strain Name：C57BL/6Smoc-Cd27tm3(hCD27)Fcgrt2btm2(hFCGRT2B)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210405

hCD27(2) (NM-HU-190035) was crossed with hFCGR2B (NM-HU-2000010) to generate hCD27(2)/hFCGR2B mice.

Mice

Abcd1-KO

Strain Name：C57BL/6Smoc-Abcd1em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-2106014

Exon 2 of Abcd1 gene was deleted to generate Abcd1 knockout mice.

Mice

Cx3cr1-CreERT2

Strain Name：C57BL/6Smoc-Cx3cr1em1(creERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200157
Validation Data：Presence

A creERT2-WPRE-polyA expression cassette was knocked into the Cx3cr1 gene start codon site.

Mice

hIL6R

Strain Name：C57BL/6Smoc-Il6ratm1(hIL6R)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00044

The endogenous mouse Il6ra gene was replaced by human IL-6R gene .

Mice

Shh-CreERT2

Strain Name：C57BL/6Smoc-Shhem1(CreERT2-WPRE-polyA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200145
Validation Data：Presence

A CreERT2-WPRE-polyA expression cassette was knocked into the Shh gene start codon site.

Mice

Nkx2-1-CreERT2

Strain Name：C57BL/6Smoc-Nkx2-1em1(CreERT2-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200123
Validation Data：Presence

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.

Mice

hHLA-A2.22

Strain Name：C57BL/6Smoc-H2-D1tm1(hHLA-A2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204988
Validation Data：Presence

The endogenous mice H2-D1 gene was replaced by human HLA-A2 gene.

Mice

hCRLF2

Strain Name：C57BL/6Smoc-Crlf2tm1(hCRLF2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210028
Validation Data：Presence

The endogenous mice Crlf2 gene was completely or partially replaced by human CRLF2 gene via ESC targeting.

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