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Models

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Mice

hCSF2

Strain Name：C57BL/6Smoc-Csf2tm1(CSF2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190046
Validation Data：Presence

The endogenous mouse Csf2 gene was replaced by human CSF2 gene.

Mice

hTNFR2/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Tnfrsf1btm2(hTNFRSF1B)Pdcd1tm1(hPDCD1)Cd274tm1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-220041

hTNFRSF1B(NM-HU-190010)，hPD-1(NM-HU-00015) and hPD-L1(NM-HU-00062) were crossed together to generate hTNFRSF1B/hPD-1/hPD-L1 mice.

Mice

hSOST(2)

Strain Name：C57BL/6Smoc-Sosttm2(hSOST)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215021
Validation Data：Presence

The endogenous mice Sost gene was replaced by human SOST gene. While hSOST(Stock No.NM-HU-200251) mice function similarly to hSOST(2) mice, for more detailed information please contact our technical advisor.

Mice

Arc-CreERT2

Strain Name：C57BL/6Smoc-Arcem1(CreERT2-SV40-pA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200101
Validation Data：Presence

A CreERT2 expression cassette was knocked into the Arc gene start codon site.

Mice

Isl1-CreERT2

Strain Name：C57BL/6Smoc-Isl1em1(CreERT2) Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00013
Validation Data：Presence  |  Publications：1piece

CreERT2 was inserted at the start codon (ATG site). The KI mice have a tamoxifen-inducible cre-mediated recombination system.

Mice

hIL17A

Strain Name：C57BL/6Smoc-Il17atm1(hIL17A)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00042
Validation Data：Presence

The endogenous mouse Il17a gene was replaced by human IL17A gene.

Mice

Foxn1-IRES-Cre

Strain Name：C57BL/6Smoc-Foxn1em1(IRES-iCre)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200106
Validation Data：Presence

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.

Mice

hVEGFA

Strain Name：C57BL/6Smoc-Vegfatm2(hVEGFA)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000028
Validation Data：Presence

The endogenous mouse Vegfa gene was replaced by human VEGFA gene. While hVEGFA(2)(Stock No.NM-HU-204984) mice function similarly to hVEGFA mice,for more detailed information please contact our technical advisor.

Mice

hEGFR

Strain Name：C57BL/6Smoc-Egfrtm1(hEGFR)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200227
Validation Data：Presence

The endogenous mice Egfr gene was replaced by human EGFR gene. While hEGFR(2)(Stock No.NM-HU-200232) mice have been pulled from shelves for some reasons.

Mice

hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Pdcd1tm1(hPDCD1)Cd274tm1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00100
Validation Data：Presence

hPD-1(NM-HU-00015) was crossed with hPD-L1(NM-HU-00062)to generate hPD-1/hPD-L1 mice

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