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Models

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Mice

hCCR8/hPD-1

Strain Name：C57BL/6Smoc-Ccr8tm1(hCCR8)Pdcd1tm1(hPDCD1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210400

hCCR8(NM-HU-190053) was crossed with hPD-1(NM-HU-00015) to generate hCCR8/hPD-1 mice.

Mice

hVEGFA(2)

Strain Name：C57BL/6Smoc-Vegfatm1(hVEGFA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-204984
Validation Data：Presence

The endogenous mice Vegfa gene was replaced by human VEGFA gene. While hVEGFA(Stock No.NM-HU-2000028) mice function similarly to hVEGFA(2) mice,for more detailed information please contact our technical advisor.

Mice

hFCRN

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sortm1(CAG-hFcRn)Fcgrtem1Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00109
Validation Data：Presence  |  Publications：1piece

This FcRn humanized strain is established by mating endogenous mouse Fcgrt gene Knockout mice with R26-hFcRn(FCGRT) Knock-in mice. These FcRn humanized mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations. While hFCRN(2)(Stock No.NM-HU-190070) and hFCRN(3)(Stock No.NM-HU-2000032）mice function similarly to hFCRN mice,for more detailed information please contact our technical advisor.

Mice

Slco1c1-2A-CreERT2

Strain Name：C57BL/6Smoc-Slco1c1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-200262
Validation Data：Presence

2A-CreERT2 expression cassette was knocked into the Slco1c1 gene stop codon site. Slco1c1 encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. When Slco1c1-2A-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in SLCO1C1 positive cells.

Mice

hCCR8/hCTLA-4

Strain Name：C57BL/6Smoc-Ccr8tm1(hCCR8)Ctla4tm1(hCTLA4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210435

hCCR8(NM-HU-190053) was crossed with hCTLA4(NM-HU-00014) to generate hCCR8/hCTLA4 mice.

Mice

A1cf-Flox

Strain Name：C57BL/6Smoc-A1cfem1(flox)Smoc
Strain State：Developing | Cat. NO.：NM-CKO-253742

These mice carry loxP sites flanking exon 4 of A1cf gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of A1cf gene.

Mice

Drd2-KO

Strain Name：C57BL/6Smoc-Drd2em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-190265

This Drd2 knockout mouse model was generated by knocking out the exon 3 region of the Drd2.

Mice

Pten-KO

Strain Name：C57BL/6Smoc-Ptenem3Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KO-18002

Exon5 of Pten gene was deleted to generate Pten knockout mice.

Mice

hTLR9/hOX40

Strain Name：C57BL/6Smoc-Tlr9tm1(hTLR9)Tnfrsf4tm3(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190024

This TLR9 and OX40 double knockin strain is established by crossing TLR9-HU and OX40-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.

Mice

hSEMA4D

Strain Name：C57BL/6Smoc-Sema4dtm1(hSEMA4D)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00117
Validation Data：Presence

The endogenous mouse Sema4d gene was replaced by human SEMA4D gene.

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