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Models

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Mice

hIGHG1

Strain Name：C57BL/6Smoc-Ighg1tm1(hIGHG1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225091

The endogenous mouse Ighg1 gene was replaced by human IGHG1 gene.

Mice

hCD37

Strain Name：C57BL/6Smoc-Cd37em1(hCD37)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-225029

The endogenous mouse Cd37 gene was replaced by human CD37 gene.

Mice

hSIGLEC15

Strain Name：C57BL/6Smoc-Siglec15em1(hSIGLEC15)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190037

The endogenous mouse Siglec15 gene was replaced by human SIGLEC15 gene.

Mice

Bmi1-IRES-CreERT2

Strain Name：C57BL/6Smoc-Bmi1em1(IRES-CreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200095

A IRES-CreERT2 expression cassette was knocked into the Bmi1 gene stop codon site.

Mice

C9orf72-KO

Strain Name：C57BL/6Smoc-C9orf72em1Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KO-201246

Exon 4-5 of C9orf72 gene was deleted to generate C9orf72 knockout mice.

Mice

Col1a1-TRE3G-dCas9-VPR-EGFP

Strain Name：C57BL/6Smoc-Col1a1em1(TRE3G-dCas9-VPR-eGFP-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00123

These mice harbor a TRE3G-dCas9-VPR(VP64-p65-Rta)-eGFP-pA tetracycline-controlled transcriptional activation cassette in mouse Col1a1 loci. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

Mice

Foxp3-V5-AviTag-IRES-Luc-2A-tdTomato

Strain Name：C57BL/6Smoc-Foxp3em1(V5-AviTag-IRES-luci-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-18034

A V5-AviTag-IRES-luci-2A-tdTomato expression cassette was inserted before the stop codon TGA of mouse Foxp3 gene to establish a multi-labeled knockin model with V5, Avi, luciferase and tdTomato fluorescent protein.

Mice

Cd68-IRES-CreERT2

Strain Name：C57BL/6Smoc-Cd68em1(IRES-CreERT2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200162

A IRES-CreERT2 expression cassette was knocked into the Cd68 gene stop codon site.

Mice

hPD-L1/hTIM3

Strain Name：C57BL/6Smoc-Cd274em1(hPD-L1)Havcr2em1(hHAVCR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190056

hPD-L1(NM-HU-00062) was crossed with hTIM3(NM-HU-00054) to generate hPD-L1/hTIM3.

Mice

Il18-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Il18em1(Luc-eGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00032

A Luciferase-2A-EGFP-pA cassette was inserted after ATG the start codon. The intrisic promoter drives the expression of reporter genes, which reflects the activity of Il18.

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