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Models

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Mice

hPD-L1/hCTLA-4

Strain Name：C57BL/6Smoc-Ctla4em1(hCTLA4)Cd274em1(hPD-L1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00102

hPD-L1(NM-HU-00062) was crossed with hCTLA4(NM-HU-00014)to generate hPD-1/hCTLA4 mice

Mice

hOX40L

Strain Name：C57BL/6Smoc-Tnfsf4em1(hTNFSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00070

The endogenous mouse Tnfsf gene was replaced by human TNFSF4（OX-40L） gene . While hOX40L(2)(Stock No.NM-HU-200005) mice function similarly to hOX40L mice,for more detailed information please contact our technical advisor.

Mice

hIL17F

Strain Name：C57BL/6Smoc-Il17fem2(hIL17F)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190007

The endogenous mouse Il17 gene was replaced by human IL17F gene.

Mice

Lyz2-2A-CreERT2

Strain Name：C57BL/6Smoc-Lyz2em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18018

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Lyz2 gene via homologous recombination to establish a tamoxifen inducible Lyz2-CreERT2 tool stain. This strain can be used to knockout target gene in Lyz2+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

Cck-IRES-Cre

Strain Name：C57BL/6Smoc-Cckem1(IRES-iCre-PolyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200131

A IRES-iCre-PolyA expression cassette was knocked into the Cck gene stop codon site.

Mice

hAPOE2

Strain Name：C57BL/6Smoc-Apoetm4(hAPOE2)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190013

This APOE2 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE2 corresponding sequence by homologous recombination.

Mice

hTNFRSF10B

Strain Name：C57BL/6Smoc-Tnfrsf10bem1(hTNFRSF10B)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210005

The endogenous mice Tnfrsf10B gene was replaced by human TNFRSF10B gene

Mice

Ucp1-CreERT2

Strain Name：C57BL/6Smoc-Ucp1em1(Kozak-CreERT2-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190102

A Kozak-CreERT2-WPRE-polyA expression cassette was knocked into the Ucp1 gene start codon site.

Mice

Drd2-KO

Strain Name：C57BL/6Smoc-Drd2em1Smoc
Strain State：Repository Live | Cat. NO.：NM-KO-190265

This Drd2 knockout mouse model was generated by knocking out the exon 3 region of the Drd2.

Mice

hIL4/hIL4R

Strain Name：C57BL/6Smoc-Il4tm3(hIL4)Il4ratm1(hIL4R)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-2000106

These mice are obtained through breeding of two single gene humanized mice.

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